Hi Shott,
I think it is better to wear it parallel to the muscle. It doesn’t affect the sensor reading at all, but it seems to stay on longer. When you flex your muscle, having more contact with the skin (parallel) will last longer.
As @ned mentioned, the grips are very useful!
Also, Dexcom will send you free patches. Check out this post. Call them and ask. It’s free, so it’s worth a try.
Also, @jen is one of the experts on extended wear, so I am flagging her on this post.