Here’s my fairly detailed review of the Guide (be sure to read additonal posts from me in that thread, as I add additional details/impressions).
I ended up moving back to the Contour Next One because I prefer it and can carry 100 strips in its container. But the Accu-Chek Guide was fine as far as accuracy is concerned, and the meter/strips/lancing device were fairly compact.
I used the Nano briefly years ago but can’t remember much about it. I think I mostly got it because at the time it came with the Multiclix lancing device. It has a chip in each vial of strips, and once strips expire, you can no longer use them. My Guide strips haven’t expired yet, but I plan on testing them once they do to see if they work. (I used an Accu-Chek Compact Plus and an Accu-Chek Mobile in the past, too, both of which had the expired strips issue. That’s really my biggest complaint about these meters.)
I liked the Guide enough that, if I was forced to use it, I wouldn’t be too upset.