From the transcript
- About endos offering and prescribing Afrezza
“Dr. Bode: The problem is most people (ENDOs) out there, never give this (AFREZZA) an option. They worry about the pulmonary safety opinion. They never worried about pulmonary safety, but that’s their job. Their job is to make sure that whatever medication you give that that it’s safe. And there’s clearly, from Lung Biologists and Pulmonologists and Oncologists, the (AFREZZA) is safe.”
“Dr. Jeremy Pettus
The only thing I’ve noticed, is that people, when they first start to do these dramatic inhalations, they suck vigorously and really, I feel that they can produce a cough. But it really does not take a lot of force. It’s more a calm, kind of like gentle inhalation and still get the amount of material. Like Bruce said, I wanted to say, most people used, you will most likely cough for the 1st or 2nd time, but then it goes away.
Dr. Janet McGill
Yeah, you read e-mails. People do overdo, you’re right. Have them calm down a little bit. Aim (inhaler) that it does not hit the top ( of the mouth)…(aim for the throat).”
- About the lack of tail in Affrezza (no lows long after inhalation)
“Dr. Janet McGill
"We use it (AFREZZA) also on our exercisers, who really cannot handle a tail on their insulin. Some of them are wearing some pumps and use the inhaled insulin (AFREZZA) for both meals and corrections, because the tail effect is a big problem for them.”
“Question: Safety of Inhaled Insulin (AFREZZA)
Reply: Dr. Bruce Bode: One thing, I think, is the safety. Most ENDOs won’t prescribe because of the safety. I have been around enough of these lung biologists and experts, because I’ve been involved with them for the last 10 years. They’ll convince you “it’s perfectly safe”. And the other thing, this drop of 40 mililiters, it’s like me sitting here and I go back like this, I drop 40 mililiters of my FEV1 by just lying down. That’s less that one per cent, one and a half per cent of your FEV1 overall. Lung Function: That’s the safety. But that’s hard for people to get over.”
- Lung cancer incidence in the study
"Question: Give the latest post marketing data on lung cancer:
Dr. Bode, Reply: “As far as I know, there’s no reported (cases). The ones who had lung cancer, there were a total of four, 2 during and 2 afterwards. These people - 2 of them had long standing history of smoking. One person only used it (AFREZZA) a very short time, less than a few weeks.”