Running a marathon! :D

[Eric]

@LarissaW

Did 18 yesterday and my I:C ratio ended up at 1:3,536 on the run

Welcome to infinity!!

Kinda neat, because eventually everything we discuss on FUD becomes relevant!

@Eric

4. Exercise can cause glucose uptake independent of insulin. Exercise of sufficient intensity promotes the uptake of glucose by muscles without insulin. The body is clever - exercising muscles need more fuel, so there needs to be a way to provide more fuel to them. This can happen without insulin, but only at sufficient intensity. This is where it kind of gets tricky, but basically there is one important note at the bottom that is the one thing worth hanging on to.

Not to get too deep in the weeds with it, but exercise increases uptake of glucose through what is called a “contraction mediated pathway”.

Adenylate kinase (ADK) converts 2 adenosine diphosphate (ADP) molecules into 1 adenosine triphosphate (ATP) molecule and 1 adenosine monophosphate (AMP) molecule. The ATP is hydrolyzed for energy, and the AMP attracts 5’-adenosine monophosphate-activated protein kinase (AMPK). AMPK acts in a way similar to how protein kinase B (Akt) recruits TBC1D1 (detailed in this post - Biochemistry - what does insulin actually do?! ), which releases GLUT4 to the cell surface and allows glucose uptake. Additionally, calcium ions released from the sarcoplasmic reticulum during muscle contraction also promotes GLUT4. Other pathways include ROS signaling, and nitric oxide signaling.

Bottom line, (the important part) there are redundant and overlapping pathways for glucose uptake that occur during muscle contraction (exercise) that do not rely on insulin!

Discussion from almost 2 years ago, April of 2018!

Full text in this thread.

how-exercise-increases-the-effect-of-insulin-and-carb-usage

It’s really cool to see that - no insulin, just keep needing carbs over and over! How awesome, right?!?

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@LarissaW

@Eric - did you want to tell everyone what you’re working on???

I am working on getting you to both lines - the start and the finish.

Tootsie Pops - "How Many Licks?" (Commercial, 1982)🦉

Like it says in the commercial, “…the world may never know…”

But that’s okay, because we will know.