Sometimes I think that I have too much time on my hands. This morning I ran across that the combination of immunosuppressant drugs with or without corticosteroids after solid organ transplants increases the risk of diabetes. It appears that immunosuppressant drugs can increase insulin sensitivity and actual cause the death of Beta cells.
It seems to me that this would be a real problem in pancreas or Beta cell transplants using immunosuppressant drugs would be counterproductive.
Here’s a link to one paper on the subject: