I’m wondering if your thigh gets a lot of friction from pants? Maybe I’m crazy (and it’s my boyfriend with T1 and the sensors and pump not me, so no firsthand experience here) but as a lady, my pants are tighter and I think it might rub.
Also I was thinking maybe the mastisol might be irritating? You have switched to a pretty intense regimen with lots of variables, and I’m wondering if one of those isn’t continuing to irritate your skin.
My second thought would be to call Dexcom before using them, and ask them to send you a sample of their adhesive and their additional adhesive stickers they offer to customers. You could just stick it on and see if it drove your skin nuts or not.
Also, we have used a variety of barrier wipes, and some are way better than others. Currently, we have a “skin prep” brand and I despise it. I swear I have to scrub my hands for minutes to get it off my fingers just from opening the wipes. We used to have Safe n’ Simple No-Sting Skin Barrier Film, which I got from an amazing wound care doctor up in Vacaville, CA. He hooked me up with some “samples” for EH to try, which is how I found that brand. They were much less gross and sticky. They seemed to work. (I just decided life is short and I hate those other things. So I am ordering some safe n simples off Amazon now. Thanks for the nudge. )
We also have adhesive issues at our house. Mainly with the OmniPod adhesive. But in thinking about your situation (which sucks! I am sorry about the pain and discomfort you’re experiencing!) I am hoping you’ll find something that works out soon.
If you’re going to test out any of the supplies, see if there’s a wound care place near you (big cities only) OR get ahold of a few different brands of wipes or barrier creams and paint them onto you without the sensor first. Then if you react you’ll know before going through with another sensor.