The CDCs very long response that still didn’t tell me what i wanted to know…glad you all did. Lol
Thank you for contacting CDC-INFO.
Here is the information you requested on the COVID-19 vaccine.
CDC recommends that fully vaccinated people with moderately or severely compromised immune systems should get an additional primary dose at least 28 days (4 weeks) after their second shot if they are
- age 5 years or older and completed the Pfizer-BioNTech COVID-19 vaccine primary series, or
- age 18 years or older and completed the Moderna COVID-19 vaccine primary series.
There is no maximum amount of time in which they should receive the additional primary dose. However, if someone receives their additional primary dose of mRNA COVID-19 vaccine fewer than 24 days after their second dose, the additional primary dose should be repeated. The repeat dose should be spaced after the improperly spaced dose by 28 days.
Studies indicate some immunocompromised people don’t always build the same level of immunity after vaccination the way non-immunocompromised people do. An additional primary dose may prevent serious and possibly life-threatening COVID-19 in people whose immune system may not have fully responded to their initial vaccine series.
CDC recommends that people who may be immunocompromised talk to their healthcare professional to see if they should get an additional primary dose of COVID-19 vaccine.
At this time, CDC does not recommend an additional primary dose of COVID-19 vaccine for people with moderately to severely compromised immune systems who received a single dose of Johnson & Johnson’s Janssen COVID-19 vaccine.
However, people with moderately to severely compromised immune systems who received a single dose of Johnson & Johnson’s Janssen COVID-19 vaccine at least 2 months ago (8 weeks) should receive a single COVID-19 booster vaccine dose. In most situations, Pfizer-BioNTech or Moderna COVID-19 vaccines are preferred over Johnson & Johnson’s Janssen COVID-19 vaccine for booster vaccination.
For more information about COVID-19 vaccine booster shots, visit the CDC website: COVID-19 Vaccine Booster Shots | CDC.
Currently, CDC is recommending that people with moderately to severely compromised immune systems receive an additional primary dose. This includes - but is not limited to - people who have:
- been receiving active cancer treatment for tumors or cancers of the blood
- received an organ transplant and taking medicine to suppress the immune system
- received a stem cell transplant within the last two years or taking medicine to suppress the immune system
- moderate or severe primary immunodeficiency (such as DiGeorge syndrome, Wiskott-Aldrich (whis-COT Ald-RICH) syndrome)
- advanced or untreated HIV infection
- been receiving treatment with high-dose corticosteroids or other drugs that may suppress your immune response
Talk to your healthcare professionals about your medical condition and about whether getting an additional shot is appropriate for you.
For people ages 18 years or older who received either a Pfizer-BioNTech or Moderna COVID-19 vaccine series who are moderately or severely immunocompromised, a third dose of the same mRNA vaccine should be used for the additional primary dose. If the mRNA vaccine product given for the first two doses is not available or is unknown, either mRNA COVID-19 vaccine product may be administered.
For adults who received a mixed primary series, or one dose of Pfizer-BioNTech and one dose of Moderna, either mRNA COVID-19 vaccine product may be administered as the additional primary dose. If the mRNA vaccine product given for the first two doses is not available or is unknown, either mRNA COVID-19 vaccine product may be administered.
For children and adolescents ages 5-17 years old, only the Pfizer-BioNTech COVID-19 vaccine is authorized and recommended.
Immunocompromised people may discuss with their healthcare professional whether getting an additional primary dose is appropriate for them. If your healthcare professional is not at a site administering vaccines, you may self-attest that you are recommended to receive a third dose of mRNA COVID-19 vaccine due to your medical condition. Immunocompromised people may receive a third shot wherever vaccines are offered without a prescription.
At your first vaccination appointment, you should have received a CDC COVID-19 vaccination record card that tells you what COVID-19 vaccine you received, the date you received it, and where you received it. Bring your vaccination card with you to your additional primary dose appointment so your healthcare professional can fill in the information about your additional primary dose.
There is limited information about the risks of receiving an additional primary dose of a COVID-19 vaccine. CDC and FDA are continuing to monitor the safety and effectiveness of third shots in immunocompromised people. So far, reactions reported after the third shot were similar to those reported after the first and second shots. Fatigue and pain at injection site were the most commonly reported side effects. Overall, most symptoms were mild to moderate.
If you receive an additional shot, you are encouraged to update your v-safe profile. If you experience side effects after your third shot, you may report them to v-safe and the Vaccine Adverse Event Reporting System (VAERS).
Additional primary doses are not different from other doses in the series. The ingredients in COVID-19 vaccines have not changed since they were first introduced.
If you received doses of COVID-19 vaccine prior to undergoing a bone marrow or stem cell transplant, then you should be revaccinated with a primary vaccine series at least 3 months (12 weeks) after completing your treatment.
If you are then revaccinated with a 2-dose mRNA COVID-19 vaccine primary series, an additional primary dose is recommended if you continue to have moderate to severe immune compromise. The additional primary dose of mRNA COVID-19 vaccine can be administered at least 28 days after you receive your second dose. Please talk to your healthcare professional about the appropriate timing of your vaccination.
After receiving an mRNA vaccine primary series that includes an additional mRNA vaccine dose, people 12 years of age and older with moderately to severely compromised immune systems should get booster dose after their third mRNA vaccine dose. This means they should receive a total of four COVID-19 vaccine doses. At this time, only the Pfizer-BioNTech COVID-19 vaccine is authorized and recommended for adolescents ages 12-17 years old.
Although mRNA vaccines are preferred for adults 18 years and older, J&J/Janssen COVID-19 vaccine may be considered in some situations.
If the Moderna vaccine is used as the booster dose, the booster dose volume is used, which is half the dose volume of a primary series dose or additional primary dose.
Currently, CDC does not recommend a booster dose in children with moderately to severely compromised immune systems ages 5-11 years old. As more data become available, this recommendation may be updated.
COVID-19 Vaccines for People with Moderately to Severely Compromised Immune Systems
Different COVID-19 Vaccines
Considerations for COVID-19 vaccination in moderately and severely immunocompromised people