I read the link on the details, and this struck me as kinda neat.
I posted this idea in a lounge thread (January 2019). I mentioned the idea of a “fragile insulin”, with the idea that it would have a shorter duration.
This less stable (fragile insulin!!) monomer insulin that Stanford is working on, would also certainly have a shorter duration.
24 hours sounds bad, but commercially-available fast-acting insulins only made it to 10 hours on that test. So 24 hours is actually amazing. The real breakthrough with this is the polymer additive that enabled the monomer insulin to be possible. It can also be used on other insulins to increase their stability.
I think the stress test is more like, how effective after x.x hours at x.xx degees. Or how long in an open environment to the air.
Not how long it will last in our system.
It shows that the monomer will be in and acting a lot quicker, but OUT a lot quicker as well. Which is huge! for us.