@sam I enjoyed the R/NPH vs. Analog Insulin paper. It was like a trip back down memory lane.
First off, I have to agree that you can get an ok A1C with R/NPH. If you can’t afford anything else it will give you an ok A1C and keep you alive. The cost savings on the insulin are given up on the loss of quality of life.
To me it is like washing your dirty clothes for a family of 6 by hand vs. using washing machine. You can get clean clothes doing the washing by hand and you avoid the high cost of buying a washing machine, but… washing clothes by hand takes a hell of a lot of time that you could be doing something else - like looking for a new job or applying for medicaid.
A couple of highlights:
Insulin Analogs—Is There a Compelling Case to Use Them? No!
…but only if you are a smug paternalistic doctor who does not have Type 1 diabetes and only uses A1C as a measure of success and thinks his patients should walk uphill both ways to school and be beaten every morning and every evening just in case the patient was doing something wrong.
“we insist that patients taking insulin eat a small bedtime snack and very few experience nocturnal hypoglycemia.”
The good doctor insists that his patients EAT NOW OR DIE. What you didn’t eat your bedtime snack? - You will sleep on the floor without a pillow, or blankets, and have a severe beating at 3am.
At least six studies have evaluated treatment satisfaction.
…but the paper was written in 2014 and most of the the treatment satisfaction surveys were done in the mid 1990’s before people had a chance to use the new insulin and figured out what the real benefits are and how it can be best used.
This would be like saying to someone - use afrezza the same way like you use humalog and see if you like afrezza better. I think you would argue that new technology should be used differently.
The only recent paper was…
Hsia SH. Insulin glargine compared to NPH among insulin-naïve, U.S. inner city, ethnic minority type 2 diabetic patients. Diabetes Res Clin Pract 2011
Which is probably relevant to the discussion.
Like others have said the conclusion of the paper was Type 1 patients do benefit from the newer analog basals. I would somewhat agree - I can use R just fine (although the long prebolus is a bit if a pain) but to me NPH is a pain compared to levemir.
