That is described in the blog posting this way:
The Difference Between Phase-II and Phase-II? Trials
Phase-II trials are “classic” phase-II trials; they are done after a successful Phase-I trial in type-1 diabetes. What I call Phase-II? trials are done on known safe treatments, so they don’t need Phase-I trials, but have never been tested on type-1 diabetes before. These Phase-II? trials might be Phase-II from the point of view of size and safety, but they are Phase-I in terms of effectiveness, so I’m putting them in their own category.
If this doesn’t make sense to you, or you have more questions about it, please tell me.