We are not hunks of dead meat obviously, but I thought this was a really cool visualization of how insulin travels through tissue to enter the bloodstream.
One interesting tidbit:
Heinemann1 estimated the coefficient of variability of insulin absorption to be in the range of 15 to 25% (intrapatient), whereas it was approximately 10% higher between patients (interpatient).
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Interesting read Tia. No we are not hunks of dead meat, but this research showing how insulin moves in tissue structures is pretty cool.
Interesting that they used 8mm needles. I wonder how much the vertical penetration would have been if 4mm needles were used, or if the tissue resistance is different at differing levels that might cause different diffusion patterns.
I wonder if this can help explain a bit more about why some people have infusion sites that go bad after a few days.
The massaging technique seems to be frowned on, because it might make it absorb faster and that would be…a variable! 
This is the quote you often see:
“Massaging the injection site is not recommended as it increases the absorption rate, which may lead to unpredictable results.”
But I do that all the time to speed it up. Been doing that since before the dawn of time.
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From looking at this study, it seems that a larger amount of insulin in an injection would spread out more and be diffused quicker. If I am correct with that thought, it would seem that using U200 or U300 products would not be as effective as just using more of the U100. Is that true, or am I missing something? (I know that using U100 may not be possible for people if their quantities are too large, but just wondering if the bigger volume of fluid is just a benefit…).
I have a diluted pen so that I can take 0.1 unit increments. I usually only use it for 0.1 to 0.4 units, and go with the normal pen for 0.5 and more. But maybe using more volume is better?