Yes, the problem with glucagon is that you don’t know what is in the liver, or if it is pre-occupied.
Glucagon is super easy for loved ones, spouses, or parents to use. But smart and savvy paramedics should not rely on it. They should always opt for injecting dextrose intravenously instead of using glucagon. With dextrose, there is no question about it.
Imagine giving glucagon to someone who had just finished running a marathon and then passed out from a low. It would be totally worthless, their liver wouldn’t have much to give.
Or someone who has been binge drinking or starving themselves. All kinds of variables there.