A clinical screening tool identifies autoimmune diabetes in adults;
Fourlanos et al; Diabetes Care; 2006 May;29(5):970-5.
CONCLUSIONS: At least two [of 5] distinguishing clinical features are found in a majority of patients with LADA at diagnosis and can be used to identify adults with diabetes at higher risk for LADA.
tl;dr: On the basis of these findings, five distinguishing clinical features were significantly more frequent in subjects with LADA than in subjects with type 2 diabetes at diagnosis (Fig. 1). These were
- age of diabetes onset <50 years
- acute symptoms of polydipsia and/or polyuria and/or unintentional weight loss before diagnosis
- BMI <25 kg/m2
- a personal history of DR3- and/or DR4-related autoimmune disease
- a family history of DR3- and/or DR4-related autoimmune disease.
A majority (75%) of subjects with LADA and a minority (24%) of type 2 diabetic subjects had at least two distinguishing clinical features (LADA clinical risk score ≥2).
