Vertex 264 trial fails :(

Vertex news release on Friday: their 264 trial (encapsulated/protected islet cell device) failed in their phase 1/2 trial and they are not pursuing it further. This is so disappointing – I had high hopes about the success of this and a “cure” coming soon. The Vertex 880 program (with immunosuppression) is continuing, which indicates that the “envelope” device is what didn’t work, rather than the cells themselves, which is still positive news.

https://investors.vrtx.com/news-releases/news-release-details/vertex-announces-program-updates-type-1-diabetes-portfolio

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Thanks for posting this, I hadn’t seen or heard about it. Sorry to hear it didn’t work, but I seem to recall and Thomas Edison quote that he “just found a way NOT to do it” rather than it can’t be done. I believe there are other methods of islet cell delivery without requiring immunosuppressants, here’s hoping they have more success!

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