Tresiba experiment

There is an app for that! Xdrip does both IOB and COB calculations…

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@Jen, how was the night? Were you still low?

I know it is very stressful not to be in range. Hang in there! So many of us are keeping our fingers crossed for you in this experiment!!!

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Yes. I must’ve treated ten lows yesterday. Aside from the spike around noon (which took a few hours to bring down) I was low all evening despite steadily munching glucose tablets.

I took 37 units last night. Overnight I was low until 1:00 AM, at which point I began rising until I hit 11 mmol/L at 3:00 AM. Then, with no correction, I began dropping back down until I was again low.

This rising-then-falling is a pattern I’ve seen while using the pump (specifically since starting metformin and eliminating my DP) and just adjusted basalt to keep me flat. I’m not sure how to handle it on MDI.

This morning is looking like it may shape up to be all lows again. I should note that I disconnect ted my pump last night, just in case that 0.6 u/he basal was having an effect.

If I continue low all day today I’m tempted to drop the Tresiba dose by several units. But I already feel like I’m adjusting more than I “should” (36, 40,38, and 37 units within six days).

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I’ve been having trouble with Levemir lately which is really disappointing given how well it had been working. It’s getting annoying too since I feel like my life is tied to my phone alarms to inject. I’m trying Tresiba again before deciding to go back to the pump, let’s see how this goes!

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@Scotteric, what a bummer that you are having trouble w Levemir :frowning:

Why not start another Tresiba startup thread to share how it is going with you?

Good luck! I hope it works for you!

I’ve been continuing to run low all day today, so I’m thinking I’ll do 35 units tonight…,

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Be careful not to overshoot!

Yeah, maybe I’ll do 36, in which case I’ll be back where I started with the crazy highs. But I’m at my parents’ place, and even they are commenting at the number of times they’ve seen me eating glucose tablets!

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Thanks Michel, I’ll post if I have anything interesting to add and start a new thread if I think I have enough to say! Enjoy the rest of your trip in la belle province, I went to McGill and Montreal will always feel like a 2nd home (stay away from Canadiens fans though, they’re crazy)! I So far I was stable all day and most of the night, which I think was helped by going from Levemir straight to Tresiba instead of from a pump where I would have no residual basal in my system. I had a big spike starting around 4am though. I am hoping the Tresiba just needs time to build up or I need to increase my dose and that it isn’t just DP that Tresiba is too flat to prevent. I am taking my dose in the morning, I wonder if this is a problem too.

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So last night I actually fell asleep without doing my Tresiba shot. We’ll blame turkey. So I took 36 units this morning.

I saw a similar pattern to the previous night. I was low all day again, hovered around 7-8 mmol/L after dinner, had a sharp rise to 10 mmol/L at around 12:30 AM (while sleeping), and then with no bolts gradually dropped to 3.4 mmol/L by the time I woke up.

I ate two glucose tablets, which shot me up to 7.8 mmol/L, but am again dropping down.

We’ll see how today goes. I may go to 35 or 34 units if I continue running low. But I also don’t want to overshoot or adjust too much. So it’s a tough balance.

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On the pump what is your normal basal profile for day versus night? Not counting fluctuations when you have to adjust basal up or down, but in general is it relatively flat 24 hours or are you higher in evening or daytime?

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My basal rate was lowest from 12:00 AM until 7:00 AM, increased from 7:00 AM until 1:00 PM, low again from 1:00 PM until 5:00 PM, had another increase from 5:00 PM until 10:00 PM, and then decreased a bit before dropping again at midnight.

My basal rates varied by about 1.2 or so units an hour from lowest to highest basal rates.

These may not be totally exact without checking on Diasend, but it’s the general pattern.

Mine are somewhat opposite, they are higher at night. But that’s part of the reason Tresiba by itself doesn’t work well for me. For people with a 24 hour flat profile and consistent needs from one day to the next it would seem to make more sense.

There are people out there, though, who claim that Tresiba takes care of variable basal needs so that they become irrelevant. So I wanted to give it a try. (My basal needs used to be opposite, too, with a peak after midnight and in the evening, but metformin has eliminated the after-midnight peak and made it the lowest basal of the 24-hour period, so evening is now my highest.)

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For some people this is the case, for others it may not be… only way to find out who’s who is to try it… I’m glad you’re trying it out

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So far today I’ve actually been running high (aside from this morning’s low). So I still don’t have the dose right, it seems. It’ll be interesting to see if I still get the overnight drop even with running high. Not sure where within this 36, 37, 38 units is right. I’m glad I got more than a week and a half worth of Tresiba, because a week in I’ve either been running too high or too low the entire time. I’m thinking that variable basal needs throughout the day may make the “right” dose impossible to find, and I may have to choose between treating lows all day or treating highs all day depending on what keeps me from dropping 6+ mmol/L over the latter half of the night.

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I am wondering how much of a role taking metformin is affecting your Triseba testing…(not suggesting discontinuing it, and am curious what role it plays)?

Metformin has flattened out my basal rates, in a way, by eliminating the highest basal rate of the day (that being the one to cover my dawn phenomenon). So I suspect it’s helping…but I could be wrong. I’ve been taking metformin for four months now, so it’s not a new medication.

Yes, I knew it wasn’t a new thing. But I wondered if it didn’t tweak the Triseba effects somehow?

I’m glad it knocked down the DP stuff - that seems helpful.

I’m not sure. I had variable basal rates (even more so) before metforming, so I think either way Tresiba would be having difficulty covering my needs throughout the entire day and night.

Before I started metformin I had a very high basal rate that used to kick in between 4:00 AM and 7:00 AM, and that’s the part that’s been eliminated (now I just have a single basal rate from midnight until 7:00 AM). So I think if that were there, my overnight readings would just be even more wacky than they are.

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