I started Tresiba 3 nights ago, after finally getting a prescription from my doctor. I’d like to share my experience because I was looking for threads from anyone with LADA on MDI just getting started on basal, and I didn’t see one (I would happily be pointed in that direction if I just missed it). Technically I am not new to basal insulin, as I was on Levemir during my last pregnancy, but my babe is now 18 months old(!), so it’s been a while, and I have never taken Tresiba.
My fasting levels have been sitting around 100-130 the past month or so (and around the 100 place for months before that). So far on Tresiba I’ve seen 95, 105, and 107 first thing in the AM. I’m currently doing 4u, so tonight or tomorrow night I will bump up to 6u and see how that goes (haven’t decided yet with my husband’s work schedule which day would be worse to potentially have lows while home alone with the kids). The bad thing is the timing of those lower fasting numbers could also just be a hormonal influence, so it’s hard to tell yet whether or not the Tresiba at this dose is doing anything at all. On the other hand, even if hormones are in play, this is the lowest insulin resistance portion of my cycle, so it’s not like I’m getting up to max dose when I’m also at max insulin resistance, which would then of course be too much when that dropped later in the month.
The main interesting thing I’ve noticed so far is that, while my numbers have been higher pre-basal, most nights I still maintained a relatively flat line, even if that flat line was sitting around 120. Now that I’m taking Tresiba, though, I do not have a flat line at all, day or night. I experienced this when I began Novolog, too - my beta cells were straining so hard to maintain decent BG levels (and they couldn’t), I introduced exogenous insulin, and the beta cells suddenly just stopped doing anything for a short period of time until I guess they’d had a sufficient break. It’s always really “cool” to see, even if I’d prefer that flat line.