Someone may be able to distill what I’m about to say in a clearer, concise question…but I’m going to brain dump it here to try to get there myself:
I have to change how I dose Humalog for meals based on a million factors. Humalog, from my perspective, is somewhat volatile based on how one dose in one situation is great and using the same dose in a different situation is just asking for tons of trouble. I’m not bagging on Humalog (really, I’m bagging on T1D). I’m just observing the number of factors that influence my body’s ability to make use of it in different scenarios.
For me, Novolog was very crisp…but it seemed to have a much smaller margin of error for me. In other words, the percentage of bolus changes I would make for a meal with Humalog for expecting to be sedentary after a meal would be way too much using Novolog.
Beyond that, thinking of fast acting insulins for basal vs long acting insulins for basal…maybe @Sam has had such a good run with Tresiba because it isn’t as amplified by exercise/stress/inactivity/etc? Or maybe his basal needs really are less variable than others?
I haven’t doubted @Sam’s testimony of his experiences on other threads at all. But it does make me wonder about if different insulins show different stability through varying conditions.
@Eric may have already answered this question with his information above.
What I liked about MDI was that there was only so much that I could change. There were pitfalls, but I could plan around those to a palatable extent up until I went off of birth control. Once I went off of birth control, Lantus’ tendencies and properties no longer met my safety needs for a variety of reasons. But that doesn’t change my intellectual question regarding stability through various conditions impacting insulin sensitivity.