Help Finding a Paper

[Chris]

I can’t seem to find the reference, but someone recently posted a great graphic about Alpha and Beta cell activity graphed against number of years since diagnosis. The graph went out to 10 or 15 years and showed that some people still had significant activity in both cell types and went a long way to explaining WYDMV in my mind. Does anyone remember that graphic and can they point me to it, or the source.

Thanks

[EdD]

I didn’t see the original post.

Maybe this or one of the references?

nihms963683.pdf

[Chris]

That is a great paper, it doesn’t have the graph I am looking for, but I think you are right I might be able to find it in the references. Thanks for posting.

[MM2]

Maybe this one

Remaining insulin production in type 1 prevalent

I went from the science news article back to the actual scientific paper at http://care.diabetesjournals.org/content/diacare/early/2017/06/13/dc16-2121.full.pdf to better understand what they found in terms of these type 1’s who are still producing insulin. First some background so the numbers make sense. They used an “ultra-sensitive ELISA” test to look for c-peptide. For this test, they set 1.17 pmol/L as the minimum detection level: anything below was considered “no measurable c-peptide.” …

[Tapestry]

@Chris

Alpha and Beta cell activity graphed against number of years since diagnosis.

Is this what you’re looking for?

Odds of developing Type 1 Diabetes after a positive Trialnet test

What are the odds of your child being diagnosed with Type 1 Diabetes (T1D) if he or she tests positive to a Trialnet antibody test? What itsTrialNet? TrialNet is a multinational project and set of trials, supported by the ADA, the JDRF, and the NIH among others. It aims to detect (and in a later stage prevent) Type 1 Diabetes as early as possible, if possible before symptoms have appeared. Since relatives of T1Ds are more likely to become T1Ds themselves, the project aims to test siblings, chi…

@Chris Edited to add: Or, another:

Study: Statistics of diabetes onset by age for Trialnet tests

This excellent 2013 study gives updated results as of 2013 for diabetes diagnosis stats (and likely prediction) for subjects who took the 5 Trialnet autoantibody tests, but looks at it by subject age instead of number of years after testing. The population size is large (more than 15,000). Here is the statistics curve, with a 15-year+ horizon: [15YearStatsTrialnetDiag] courtesy Ziegler AG, Rewers M, Simell O, et al. Seroconversion to Multiple Islet Autoantibodies and Risk of Progression t…