Ever had a weird reported lowness like this?

My meter said 35. I checked a different meter, and it said 31. Rechecked first meter, and it said 34.

I feel fine. Dexcom is saying I am low.

Another meter check, and it again said 35.

?

Really feel fine still.

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Nope; I’d probably be nearly unconscious at that BG. Personally, feelings aside, I’d trust the (multiple) meters, but I live alone and can’t afford to make an error of undertreating a low.

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I still don’t know what was going on. I ate a few crackers, just to be on the safe side. Nothing very sweet. And about 30 minutes later, my BG was 134. So I still don’t know if I was actually low.

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Definitely weird! :flushed_face:

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I would trust multiple meters. Are you still hypo alert?

The lowest Liam ever got was 28 and i was scared senseless…he was very drowsy and I was about to give Baqsimi when he started coming to again (he had already had fast carbs earlier). He’s been in the 30s a few times over the years…equally as scary.

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I generally know before my Dexcom does!

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When I see the Endo he seems amazed I’m still hypo aware. Then again I think he’s amazed I’m still alive…lol

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You’re so lucky you’re hypo aware…. my awareness has been gone for a long time!! Went to the clubs 25ish years ago with my boyfriend (now my husband), came out of a club, and my meter said 29.

I didn’t feel it - hubs said I was falling asleep trying to cross the street to our car. I got orange juice, and everything worked out. But I saw that meter read 29, and that’s the lowest I’ve ever been conscious enough to remember!

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It’s so weird – I totally understand feeling fiiiine in the 40s, but whacked out shaky low in the low 70s. I don’t know what’s going on these days.

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A few crackers could send my bg up by 100mg/dL in around 20 minutes; 20g of crackers (3 crackers possibly) on an empty stomach but, like you I suspect, I’ve never been near 30mg/dL and not known about it 5 minutes before.

I see only two possibilities:

  1. Low interstitial blood glucose in the fingers (I’m assuming literal fingersticks here) caused by extreme conditions, maybe cold or rapid finger exercise; I’m BSing here but it does seem possible.

  2. A chemical interference with the BG meter test strips (I’m discounting the Dexcom because in my experience it can say otherwise hilarious things at quite reasonable BG). There’s a long list of things that can mess up test strips and, for that matter, CGMs; Linus Pauling’s favourite (ascorbic acid) comes first.

Both effects are in the fingers (unless you were testing somewhere else, toes?) So something localised lasting for less than 30 minutes. I don’t think the CGM reading is relevant; yeah, maybe it is somewhere different but the darned thing is so inaccurate below 100mg/dL.

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That’s the feeling. It’s not like being drunk, or tired, or just plain worn out. It’s an inability to focus, yes, a slight unsteadiness like inebriation, but a feeling of being BG low.

I don’t think non-Ds understand it; most non-Ds seem not to be hypo-aware even though many, perhaps all, of them suffer from hypos now and then. It is not something we lose; it is something we develop and more and more.

Sometimes these days I feel I’m going low when by BG is, according to all the devices, around 90mg/dL. That’s not because I’m accustomed to high BG; these days with modern tech my average BG (HbA1C, TIR etc) is much much lower than it ever was. Maybe I’m hyposensitive?

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The Brains and the Fingers blood supply and their glucose content can be at times far different because the Brain is supplied from arterial blood compared to the capillaries in your fingers where you get finger sticks from, it’s possible this can vary by a lot depending on the situation. The body (finger capillaries) in my example could be (say) 1 mmol ~ 18 mg/dl while the Brian’s blood sugar (from arterial supply) maybe (say) 5 mmol ~ 90 mg/dl. This is often why you will have extremely low blood sugars that you read from a finger stick but still be conscious and feeling ok. It’s not lying to you or in error, it’s that the brain and capillaries are out of ā€˜sync’, but if you stay low for long enough they will eventually reach ā€˜parity’. Bernstein had video on this as someone wrote in to him and asked him this question.

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Extraordinary claims require extraordinary evidence. I want to read three high quality references before I believe that statement.

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It’s not a scientific statement, it’s just what Bernstein said and I can say from 50 years of type one at every stage of life it appears true in that at 1.8 mmol I’ve been quite conscious and I’ve also at 3.2 had to be revived by paramedics. It should be clear that CGM blood differs up to 15 minutes behind venous gas, so it shouldn’t be a stretch to think that the brain is behind or in front of the venous supply. Now, I’m unsure if this can cause significant differences that could explain that situation I wouldnt know, I’m not a Dr, but I certainly don’t think it’s ā€˜extraordinary’ in any way, it’s either true or it’s not, but I would like to know why this happens, I guess when I heard Bernstein say it, it made sense but now you ask I’m very curious.

EDIT: Turns out Chatgpt agrees with Bernstein, here’s what Chatgpt said, but again like you said, you wouldn’t want to trust this information, verify it if it’s important:

Great question — you’re digging right into the physiology of brain glucose vs. peripheral glucose and why Dr. Richard Bernstein talks about this difference.

1. Blood glucose is not the same everywhere in the body, when you prick your finger, you’re measuring glucose in capillary blood from the periphery, the brain, however, gets glucose delivered through the cerebral circulation and across the blood–brain barrier (BBB).

The concentration in finger blood, venous blood, and interstitial fluid (where CGMs measure) can differ, especially when glucose is changing quickly.

2. The blood–brain barrier (BBB) acts like a buffer

Glucose crosses the BBB mainly via the GLUT1 transporter, which is saturable and maintains a fairly stable supply to neurons.

Because of this, brain interstitial glucose lags behind and smooths out rapid changes in blood glucose.

So if your meter shows a very fast drop to 1.8 mmol/L, your brain may still have ~3–4 mmol/L in its interstitial space for a while.

This ā€œreserveā€ is what can keep you conscious at readings that look dangerously low.

4. Other factors that explain the difference

Counter-regulatory hormones (adrenaline, cortisol, growth hormone, glucagon) affect symptoms, not just numbers.

Adaptation: people with tight control or recurrent hypos sometimes tolerate much lower glucose before losing consciousness — the brain adapts to run on less glucose.

Alternative fuels: in prolonged low states, the brain can burn more ketones or lactate, temporarily sparing glucose.

:white_check_mark: So in short:

Finger-stick glucose ≠ brain glucose.

The BBB smooths and lags changes, so your brain can have more fuel than your meter suggests (keeping you conscious at scary-low numbers).

Once the gradient collapses, IV glucose is needed to push enough sugar into the brain to restore functi

Do you want me to sketch out a timeline/graph that shows finger glucose dropping fast, brain glucose lagging behind, and wh

ere consciousness fails? That would make this much clearer visually.

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@genix While I appreciate the capabilities of ChatGPT and other AI systems and have found those of Google and others usually relatively correct, I know from experience with the few I’ve tried that their responses can be skewed by how a question or request is phrased. In addition, there have been significant errors reported based on sources trusted to ā€œtrainā€ an AI system which also skews the information concluded or provided by AI systems. My take: AI systems usually make for a decent, if not great, starting point but require review, confirmation, and verification by users, particularly those that didn’t design or haven’t developed a history with a particular AI and determined a level of trust for it.

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@eric has mentioned something like this before! I don’t know that it relates to arterial blood necessarily… but he’d mentioned, ā€œThe brain uses the GLUT3 glucose transport. Since GLUT3 is a high-affinity glucose transporter, only a small amount of glucose is needed to saturate it.ā€ More info and reference here: Fixing the Low to High Rollercoaster - #2 by Eric

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Coming late to this fascinating thread. As we all know, Dexcom can be completely whacky - especially in the first day after insertion. I’d say I have false ā€œurgent lowā€ readings about 25% of the time with new Dexcom sensors.

But this is a different issue, and I appreciate all the hypotheses, both @jbowler and @genix

Genix’ explanation seems plausible to me even if it doesn’t have a lot of scientific studies.

Another explanation, which is more worrisome for @eric, is that he’s losing his ability to tell when he’s going low.
Hope that doesn’t turn out to be the case.

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Well I don’t know what happened in this case, but I’ve been beating the Dexcom to the low all day today!

:man_shrugging:

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I think it’s 100% for me. It is certainly true that I have got low enough, maybe approaching 60mg/dL on a fingerstick, to trigger a Dexcom alert but, like @eric, I always knew before the CGM ever got there. I’ve had a few, not a lot but a significant few, of Dexcom false alerts. They happened in the morning mostly. They seem to happen when I am particularly insulin sensitive and go out and do stuff that would use the insulin sensitivity, I think…

My data is from memory and is apocryphal. I really wish my ā€˜phone would log my exercise level and that xDrip+ could read that and send it to NightScout but then I’d need NightScout to produce data in a format that was considerably more amenable to my own data processing abilities.

What @genix said is entirely consistent with what I said; the two statements are at fundamentally different levels in the process, though I should have said ā€œlow capillary blood glucose in the fingersā€. @genix provides an explanation based on the buffering of glucose in the brain. I don’t think the different transports are relevant to the explanation.

The buffer damps venous variations in BG, so a spike (down) in BG can occur in the core blood system (veins and arteries) and be reflected in the capillaries without ever being seen behind the blood brain barrier. That’s kinda useful :slight_smile: @eric didn’t say if his BG had descended ā€œrapidlyā€ and the limited amount of research I could find didn’t give me a half-life for the damping; if it’s 1/2 hour 15 minute variations will disappear etc [rule of thumb.]

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The Chatgpt thing was to show It agrees with Bernstein, after all it’s him that made this claim first, and I find I agree with Bernstein, Medical school physiology and chatgpt in their instance and all the power to you especially on the Chatgpt front, and again I’m not going to find first year medical texts to show interstitial fluid, venous blood, capillary blood, and both arterial blood and arterial blood gasses along with the blood brain barrier (barrier being the key word) aren’t all separated systems. I will guarantee though they are all separated and can have vastly differing glucose values especially the brain which has mechanisms to protect itself from sudden changes in many things including glucose.