Aggressive and Devastating Neuropathy: Untreated LADA

britt_j
Mon, 01 May 2017 15:19:29 +0000
Complications & More

Aggressive and devastating neuropathy: the consequence of untreated slow-onset type 1 diabetes by P. Narendran et al; QJM (2011) 104 (6): 523-526 | DOI: Aggressive and devastating neuropathy: the consequence of untreated slow-onset type 1 diabetes | QJM: An International Journal of Medicine | Oxford Academic; Published: 27 July 2010

We describe two cases of T1D where a period of undiagnosed and untreated hyperglycaemia resulted in the aggressive onset of microvascular complications. These cases support our previous understanding that T1D can present with preceding prolonged hyperglycaemia but go on to illustrate for the first time that this hyperglycaemia can result in diabetic complications. The phenomenon of undiagnosed diabetes resulting in complications is well recognized in type 2 diabetes (T2D), where a significant proportion of patients have a complication at the time of diagnosis, but as far as we are aware this has not been described in T1D.

There are clear similarities between these cases (young white Caucasian adult males, insidious presentation of T1D, initial aggressive development of neurological and other microvascular complications with a subsequent stabilization), and they may form a distinct variant of T1D.

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