A Clinical Screening Tool Identifies T1 in Adults

britt_j
Sun, 23 Apr 2017 04:09:24 +0000
Type 1 & LADA

A clinical screening tool identifies autoimmune diabetes in adults;
Fourlanos et al; Diabetes Care; 2006 May;29(5):970-5.

CONCLUSIONS: At least two [of 5] distinguishing clinical features are found in a majority of patients with LADA at diagnosis and can be used to identify adults with diabetes at higher risk for LADA.

tl;dr: On the basis of these findings, five distinguishing clinical features were significantly more frequent in subjects with LADA than in subjects with type 2 diabetes at diagnosis (Fig. 1). These were

1. age of diabetes onset <50 years

2. acute symptoms of polydipsia and/or polyuria and/or unintentional weight loss before diagnosis

3. BMI <25 kg/m2

4. a personal history of DR3- and/or DR4-related autoimmune disease

5. a family history of DR3- and/or DR4-related autoimmune disease.

A majority (75%) of subjects with LADA and a minority (24%) of type 2 diabetic subjects had at least two distinguishing clinical features (LADA clinical risk score ≥2).

PubMed

A clinical screening tool identifies autoimmune diabetes in adults - PubMed

At least two distinguishing clinical features are found in a majority of patients with LADA at diagnosis and can be used to identify adults with diabetes at higher risk for LADA.

4 posts - 3 participants

Read full topic