# Zealand's shelf-stable glucagon formulation is approved

**URL:** <https://forum.fudiabetes.org/t/zealands-shelf-stable-glucagon-formulation-is-approved/11201>\
**Category:** Medicines\
**Created:** [April 6, 2021, 5:50pm UTC](https://forum.fudiabetes.org/t/zealands-shelf-stable-glucagon-formulation-is-approved/11201 "2021-04-06T17:50:52Z")\
**Posts on this page:** 6\
**Page:** 1

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**Author:** ![TiaG](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/tiag/32/594_2.png) [@TiaG](https://forum.fudiabetes.org/u/TiaG)\
**Post date:** [April 6, 2021, 5:50pm UTC](https://forum.fudiabetes.org/t/zealands-shelf-stable-glucagon-formulation-is-approved/11201/1 "2021-04-06T17:50:52Z")

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Story here:

> **[Zegalogue – New Emergency Glucagon Approved for Adults and Kids in US](https://diatribe.org/zegalogue-new-emergency-glucagon-approved-adults-and-kids-us?utm_source=twitter&utm_medium=organic)**
>
> Zegalogue emergency glucagon comes as a pre-filled injection or auto-injector pen and can be used to treat severe hypoglycemia quickly.

Here’s hoping a microdose option and a pump option become available soon!

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**Author:** ![Eric](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/eric/32/9209_2.png) [@Eric](https://forum.fudiabetes.org/u/Eric)\
**Post date:** [April 6, 2021, 6:07pm UTC](https://forum.fudiabetes.org/t/zealands-shelf-stable-glucagon-formulation-is-approved/11201/2 "2021-04-06T18:07:54Z")

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This stuck me as hilarious!

[www.primetherapeutics.com/en/news/Stories/2021/Story-Decisions-expected-FDA-March.html](https://www.primetherapeutics.com/en/news/Stories/2021/Story-Decisions-expected-FDA-March.html)

> **3/27/2021: Zegalogue™ (dasiglucagon) HypoPal® Rescue Pen**
> 
> Zealand Pharma’s Zegalogue HypoPal Rescue Pen is seeking approval from the FDA as a glucagon analog, stable in liquid formulation as a ready-to-use pen injector for treatment of severe hypoglycemia in patients with diabetes. Zegalogue was tested in both adults and pediatrics in three Phase 3 clinical trials. Zegalogue met the primary and all key secondary endpoints, demonstrating a median time to blood glucose recovery of 10 minutes. **This compared to 40 minutes with placebo** and 12 minutes with GlucaGen.

How would you like to be one of the participants in a trial testing a glucagon rescue pen, and you get the… placebo!!

**WTH??!** Thanks a lot, clinical trial overlords!

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**Author:** ![TiaG](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/tiag/32/594_2.png) [@TiaG](https://forum.fudiabetes.org/u/TiaG)\
**Post date:** [April 6, 2021, 6:24pm UTC](https://forum.fudiabetes.org/t/zealands-shelf-stable-glucagon-formulation-is-approved/11201/3 "2021-04-06T18:24:55Z")

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I know, I’m confused by this, who volunteers to have their blood sugar lowered to 40 mg/DL and then just sit around at that level???

Also it feels like the appropriate comparator is regular glucagon.

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**Author:** ![Chris](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/chris/32/382_2.png) [@Chris](https://forum.fudiabetes.org/u/Chris)\
**Post date:** [April 6, 2021, 8:09pm UTC](https://forum.fudiabetes.org/t/zealands-shelf-stable-glucagon-formulation-is-approved/11201/4 "2021-04-06T20:09:00Z")

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Can you imagine just sitting around at 40 for 40 minutes. That doesn’t sound like fun in my book. Hope they compensated the patients well.

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**Author:** ![ClaudnDaye](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/claudndaye/32/5_2.png) [@ClaudnDaye](https://forum.fudiabetes.org/u/ClaudnDaye)\
**Post date:** [April 6, 2021, 10:41pm UTC](https://forum.fudiabetes.org/t/zealands-shelf-stable-glucagon-formulation-is-approved/11201/5 "2021-04-06T22:41:10Z")

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> [@TiaG](#):
>
> who volunteers to have their blood sugar lowered to 40 mg/DL and then just sit around at that level???

@Eric? 😆 … Only the bravest souls.

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**Author:** ![Eric](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/eric/32/9209_2.png) [@Eric](https://forum.fudiabetes.org/u/Eric)\
**Post date:** [April 7, 2021, 1:29am UTC](https://forum.fudiabetes.org/t/zealands-shelf-stable-glucagon-formulation-is-approved/11201/6 "2021-04-07T01:29:55Z")

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Yeah, sometimes I do that when there isn’t even a research study going on. 😀