# Xeris Pharmaceuticals Achieves Phase 3 Milestones of its Ready-to-Use Glucagon Rescue Pen **URL:** \ **Category:** D-News\ **Created:** [February 21, 2018, 6:02pm UTC](https://forum.fudiabetes.org/t/xeris-pharmaceuticals-achieves-phase-3-milestones-of-its-ready-to-use-glucagon-rescue-pen/3546 "2018-02-21T18:02:11Z")\ **Posts on this page:** 8\ **Page:** 1
**Author:** ![Boerenkool](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/boerenkool/32/6307_2.png) [@Boerenkool](https://forum.fudiabetes.org/u/Boerenkool)\ **Post date:** [February 21, 2018, 6:02pm UTC](https://forum.fudiabetes.org/t/xeris-pharmaceuticals-achieves-phase-3-milestones-of-its-ready-to-use-glucagon-rescue-pen/3546/1 "2018-02-21T18:02:11Z")
Due to a conversation last week, I was wondering about the auto-injector pen which is being developed by Xeris. I found this article from last week. They’re still developing the pen and have completed two Phase 3 studies and will start a Phase 3b study: [https://globenewswire.com/news-release/2018/02/15/1349229/0/en/Xeris-Pharmaceuticals-Achieves-Phase-3-Milestones-of-its-Ready-to-Use-Glucagon-Rescue-Pen-for-the-Treatment-of-Severe-Hypoglycemia.html](https://globenewswire.com/news-release/2018/02/15/1349229/0/en/Xeris-Pharmaceuticals-Achieves-Phase-3-Milestones-of-its-Ready-to-Use-Glucagon-Rescue-Pen-for-the-Treatment-of-Severe-Hypoglycemia.html) ---
**Author:** ![Jen](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/jen/32/4777_2.png) [@Jen](https://forum.fudiabetes.org/u/Jen)\ **Post date:** [February 21, 2018, 6:37pm UTC](https://forum.fudiabetes.org/t/xeris-pharmaceuticals-achieves-phase-3-milestones-of-its-ready-to-use-glucagon-rescue-pen/3546/2 "2018-02-21T18:37:29Z")
This is exciting! I noticed that it appears this company is doing clinical trials of their mini-dose pens (different from their auto-injector) in Canada. I’m planning to ask my endocrinologist about it at my next appointment. ---
**Author:** ![Chris](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/chris/32/382_2.png) [@Chris](https://forum.fudiabetes.org/u/Chris)\ **Post date:** [February 21, 2018, 7:09pm UTC](https://forum.fudiabetes.org/t/xeris-pharmaceuticals-achieves-phase-3-milestones-of-its-ready-to-use-glucagon-rescue-pen/3546/3 "2018-02-21T19:09:02Z")
Really good news, that would be “Awesomer” than the ready mix vials currently in use. ---
**Author:** ![bkh](https://avatars.discourse-cdn.com/v4/letter/b/da6949/32.png) [@bkh](https://forum.fudiabetes.org/u/bkh)\ **Post date:** [February 21, 2018, 9:08pm UTC](https://forum.fudiabetes.org/t/xeris-pharmaceuticals-achieves-phase-3-milestones-of-its-ready-to-use-glucagon-rescue-pen/3546/4 "2018-02-21T21:08:08Z")
[https://www.healthline.com/diabetesmine/glucagon-updates](https://www.healthline.com/diabetesmine/glucagon-updates) describes three kinds of stable glucagon (one is the one from Xeris) that are in the works. One is a nasal spray, two are stable injectable liquids. Those two are both described as suitable for insulin pumps (for dual-hormone AP.) The article offers the hope that we could see 2 of the 3 available in 2018, at least for rescue dosing if not microdosing too. ---
**Author:** ![Michel](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/michel/32/387_2.png) [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Post date:** [February 21, 2018, 9:43pm UTC](https://forum.fudiabetes.org/t/xeris-pharmaceuticals-achieves-phase-3-milestones-of-its-ready-to-use-glucagon-rescue-pen/3546/5 "2018-02-21T21:43:33Z")
@Boerenkool, @bkh, great stuff! It is great to find them making their way towards some products, I was losing hope on them. Now let’s hope that the trials are successful, and that pricing is not outrageous. ---
**Author:** ![katiereeder](https://avatars.discourse-cdn.com/v4/letter/k/e79b87/32.png) [@katiereeder](https://forum.fudiabetes.org/u/katiereeder)\ **Post date:** [February 22, 2018, 2:15am UTC](https://forum.fudiabetes.org/t/xeris-pharmaceuticals-achieves-phase-3-milestones-of-its-ready-to-use-glucagon-rescue-pen/3546/6 "2018-02-22T02:15:55Z")
A nasal spray would be great!! Would definitely cut down on the freaked out looks on my kids’ teachers faces every year when I teach a new crop how to use the glucagon syringe kit. I think they could handle sticking something up his nose 😊 ---
**Author:** ![elver](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/elver/32/8772_2.png) [@elver](https://forum.fudiabetes.org/u/elver)\ **Post date:** [February 22, 2018, 2:53am UTC](https://forum.fudiabetes.org/t/xeris-pharmaceuticals-achieves-phase-3-milestones-of-its-ready-to-use-glucagon-rescue-pen/3546/7 "2018-02-22T02:53:33Z")
I just (last 20 minutes or so) did a survey that discussed the nasal glucagon. They stated that it didn’t need to be inhaled, but was absorbed by the mucus membranes. I am guessing it has some sort of propellant. My wife would certainly like that - she is gun shy of needles. ---
**Author:** ![Boerenkool](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/boerenkool/32/6307_2.png) [@Boerenkool](https://forum.fudiabetes.org/u/Boerenkool)\ **Post date:** [February 22, 2018, 10:36am UTC](https://forum.fudiabetes.org/t/xeris-pharmaceuticals-achieves-phase-3-milestones-of-its-ready-to-use-glucagon-rescue-pen/3546/8 "2018-02-22T10:36:42Z")
I hope that too. If pricing is going to be like the EpiPen, I doubt whether it will be covered by insurance. A pen like this would be such an improvement compared to current hypo kits. Currently I don’t (or rarely) carry a hypo kit with me. Sometimes people ask me why not, “Isn’t it easy, just like an EpiPen?” Well, no. No stranger knows how to use it, because it’s more difficult than that. The Phase 3B trial is in the recruitment phase, more info about the study and participating clinics can be found here: > **[G-Pen™ Compared to Lilly Glucagon for Hypoglycemia Rescue in Adults With Type 1...](https://clinicaltrials.gov/ct2/show/study/NCT03439072)** > > G-Pen™ Compared to Lilly Glucagon for Hypoglycemia Rescue in Adults With Type 1 Diabetes - Full Text View. If you search for Xeris, you can find more information about their other clinical trials concerning glucagon: [https://clinicaltrials.gov/ct2/results?cond=&term=xeris&cntry=&state=&city=&dist=](https://clinicaltrials.gov/ct2/results?cond=&term=xeris&cntry=&state=&city=&dist=)