# Vertex 264 trial fails :(

**URL:** <https://forum.fudiabetes.org/t/vertex-264-trial-fails/15209>\
**Category:** T1 Research\
**Created:** [March 30, 2025, 7:50pm UTC](https://forum.fudiabetes.org/t/vertex-264-trial-fails/15209 "2025-03-30T19:50:46Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![JessicaD](https://avatars.discourse-cdn.com/v4/letter/j/6f9a4e/32.png) [@JessicaD](https://forum.fudiabetes.org/u/JessicaD)\
**Post date:** [March 30, 2025, 7:50pm UTC](https://forum.fudiabetes.org/t/vertex-264-trial-fails/15209/1 "2025-03-30T19:50:47Z")

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Vertex news release on Friday: their 264 trial (encapsulated/protected islet cell device) failed in their phase 1/2 trial and they are not pursuing it further. This is so disappointing – I had high hopes about the success of this and a “cure” coming soon. The Vertex 880 program (with immunosuppression) is continuing, which indicates that the “envelope” device is what didn’t work, rather than the cells themselves, which is still positive news.

[https://investors.vrtx.com/news-releases/news-release-details/vertex-announces-program-updates-type-1-diabetes-portfolio](https://investors.vrtx.com/news-releases/news-release-details/vertex-announces-program-updates-type-1-diabetes-portfolio)

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**Author:** ![TomH](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/tomh/32/9063_2.png) [@TomH](https://forum.fudiabetes.org/u/TomH)\
**Post date:** [March 30, 2025, 8:17pm UTC](https://forum.fudiabetes.org/t/vertex-264-trial-fails/15209/2 "2025-03-30T20:17:05Z")

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Thanks for posting this, I hadn’t seen or heard about it. Sorry to hear it didn’t work, but I seem to recall and Thomas Edison quote that he “just found a way NOT to do it” rather than it can’t be done. I believe there are other methods of islet cell delivery without requiring immunosuppressants, here’s hoping they have more success!

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**Author:** ![funk](https://avatars.discourse-cdn.com/v4/letter/f/d07c76/32.png) [@funk](https://forum.fudiabetes.org/u/funk)\
**Post date:** [April 6, 2025, 5:51am UTC](https://forum.fudiabetes.org/t/vertex-264-trial-fails/15209/3 "2025-04-06T05:51:46Z")

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Once the explanted devices are analyzed, perhaps Vertex will be able to figure out why the encapsulation failed and if possible, design a better version for future clinical studies.