# T2D adding GLP-1 receptor agonists to usual drug regimen were somewhat (18%) less likely to suffer a first-time heart attack or stroke in coming years **URL:** \ **Category:** Medicines\ **Created:** [May 10, 2023, 5:06pm UTC](https://forum.fudiabetes.org/t/t2d-adding-glp-1-receptor-agonists-to-usual-drug-regimen-were-somewhat-18-less-likely-to-suffer-a-first-time-heart-attack-or-stroke-in-coming-years/13817 "2023-05-10T17:06:32Z")\ **Posts on this page:** 7\ **Page:** 1
**Author:** ![bwschulz](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/bwschulz/32/8869_2.png) [@bwschulz](https://forum.fudiabetes.org/u/bwschulz)\ **Post date:** [May 10, 2023, 5:06pm UTC](https://forum.fudiabetes.org/t/t2d-adding-glp-1-receptor-agonists-to-usual-drug-regimen-were-somewhat-18-less-likely-to-suffer-a-first-time-heart-attack-or-stroke-in-coming-years/13817/1 "2023-05-10T17:06:32Z")
**“Head-to-head study finds which diabetes meds are best for the heart”** from _ **U.S. News & World Report** _ summarizes a recent VA study that found Veterans with diabetes who added drugs called GLP-1 receptor agonists to their usual regimen were somewhat less likely to suffer a first-time heart attack or stroke in coming years, compared with Veterans taking other diabetes medications. Veterans on GLP-1 drugs were 18% less likely to suffer first time heart problems or stroke versus those on a DPP-4 drug, and those taking SGLT2 medications showed no heart or stroke benefit. I’m Type 1, but also on Metformin and Semaglutide, so this is good news to me. > **[Head-to-Head Study Finds Which Diabetes Meds Are Best for the Heart](https://www.usnews.com/news/health-news/articles/2023-05-09/head-to-head-study-finds-which-diabetes-meds-are-best-for-the-heart)** > > US News is a recognized leader in college, grad school, hospital, mutual fund, and car rankings. Track elected officials, research health conditions, and find news you can use in politics, business, health, and education. Full article here: [https://www.acpjournals.org/doi/10.7326/M22-2751](https://www.acpjournals.org/doi/10.7326/M22-2751) ---
**Author:** ![Jan](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/jan/32/7539_2.png) [@Jan](https://forum.fudiabetes.org/u/Jan)\ **Post date:** [May 20, 2023, 1:55pm UTC](https://forum.fudiabetes.org/t/t2d-adding-glp-1-receptor-agonists-to-usual-drug-regimen-were-somewhat-18-less-likely-to-suffer-a-first-time-heart-attack-or-stroke-in-coming-years/13817/2 "2023-05-20T13:55:34Z")
@bwschulz I’m long-time T1 and just curious, do you mind sharing why you are taking both Metformin and Semaglutide? ---
**Author:** ![CarlosLuis](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/carlosluis/32/11389_2.png) [@CarlosLuis](https://forum.fudiabetes.org/u/CarlosLuis)\ **Post date:** [May 20, 2023, 5:13pm UTC](https://forum.fudiabetes.org/t/t2d-adding-glp-1-receptor-agonists-to-usual-drug-regimen-were-somewhat-18-less-likely-to-suffer-a-first-time-heart-attack-or-stroke-in-coming-years/13817/3 "2023-05-20T17:13:16Z")
> [@Jan](#): > > I’m long-time T1 and just curious, do you mind sharing why you are taking both Metformin and Semaglutide? I don’t know it this is true for @bwschulz, but there are some type 1s who are _blesssed_ (???) with the same genetic variant of type 2. They have to deal with insulin resistance that in abnormal. By taking Metformin or other type 2 drugs can be helpful, decreasing the amount of insulin needed and improving management. The common name for this is double diabetes. [https://www.diabetes.co.uk/double-diabetes.html#:~:text=Double%20diabetes%20is%20when%20someone,resistance%20can%20be%20reduced%20somewhat](https://www.diabetes.co.uk/double-diabetes.html#:~:text=Double%20diabetes%20is%20when%20someone,resistance%20can%20be%20reduced%20somewhat). ---
**Author:** ![bwschulz](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/bwschulz/32/8869_2.png) [@bwschulz](https://forum.fudiabetes.org/u/bwschulz)\ **Post date:** [May 20, 2023, 5:56pm UTC](https://forum.fudiabetes.org/t/t2d-adding-glp-1-receptor-agonists-to-usual-drug-regimen-were-somewhat-18-less-likely-to-suffer-a-first-time-heart-attack-or-stroke-in-coming-years/13817/4 "2023-05-20T17:56:28Z")
Kind of what @CarlosLuis said- mostly insulin resistance. I’ve been on Metformin forever and I recently changed the timing of my evening dose to be just before bedtime to counteract an overnight rise in blood sugar I would otherwise get around 3AM. I tried Semaglutide recently because my overall insulin resistance has been increasing and I was hoping it would also help me lose weight. It seems to be helping with both of those goals so far. Not huge effects, but noticeably better. My insulin works more predictably and consistently and I’ve dropped 8lbs so far. ---
**Author:** ![CarlosLuis](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/carlosluis/32/11389_2.png) [@CarlosLuis](https://forum.fudiabetes.org/u/CarlosLuis)\ **Post date:** [May 20, 2023, 6:05pm UTC](https://forum.fudiabetes.org/t/t2d-adding-glp-1-receptor-agonists-to-usual-drug-regimen-were-somewhat-18-less-likely-to-suffer-a-first-time-heart-attack-or-stroke-in-coming-years/13817/5 "2023-05-20T18:05:08Z")
> [@bwschulz](#): > > My insulin works more predictably and consistently and I’ve dropped 8lbs so far. That’s great news. ---
**Author:** ![CarlosLuis](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/carlosluis/32/11389_2.png) [@CarlosLuis](https://forum.fudiabetes.org/u/CarlosLuis)\ **Post date:** [July 8, 2023, 11:00pm UTC](https://forum.fudiabetes.org/t/t2d-adding-glp-1-receptor-agonists-to-usual-drug-regimen-were-somewhat-18-less-likely-to-suffer-a-first-time-heart-attack-or-stroke-in-coming-years/13817/6 "2023-07-08T23:00:34Z")
> [@CarlosLuis](#): > > The common name for this is double diabetes. > [Double Diabetes - Insulin Resistance in Type 1 Diabetes](https://www.diabetes.co.uk/double-diabetes.html#:~:text=Double%20diabetes%20is%20when%20someone,resistance%20can%20be%20reduced%20somewhat). I guess I am too late to edit this answer. I think the more accepted name for double diabetes is type1 diabetes with insulin resistance. ---
**Author:** ![MM2](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/mm2/32/3032_2.png) [@MM2](https://forum.fudiabetes.org/u/MM2)\ **Post date:** [July 8, 2023, 11:42pm UTC](https://forum.fudiabetes.org/t/t2d-adding-glp-1-receptor-agonists-to-usual-drug-regimen-were-somewhat-18-less-likely-to-suffer-a-first-time-heart-attack-or-stroke-in-coming-years/13817/7 "2023-07-08T23:42:51Z")
And to confuse things even more… > **[The Truth About Type 3 Diabetes and Alzheimer’s Disease](https://www.masteringdiabetes.org/type3-diabetes/)** > > Understand the signs and symptoms of Type 3 Diabetes and its connection to Alzheimer’s Disease and other forms of dementia. My Mom is T2, oral meds only. Now 92. Was diagnosed with ALZ several years ago. I have had T1D 58 years, and recently dx with mild ALZ. But new treatments are becoming available.