# Sudden onset insulin resistance **URL:** \ **Category:** Type 1 & LADA\ **Created:** [October 16, 2026, 4:54am UTC](https://forum.fudiabetes.org/t/sudden-onset-insulin-resistance/16426 "2026-10-16T04:54:30Z")\ **Posts on this page:** 9\ **Page:** 1
**Author:** ![John58](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/john58/32/147_2.png) [@John58](https://forum.fudiabetes.org/u/John58)\ **Post date:** [October 16, 2026, 4:54am UTC](https://forum.fudiabetes.org/t/sudden-onset-insulin-resistance/16426/1 "2026-10-16T04:54:30Z")
“Sudden onset insulin resistance” …that’s about as descriptive as I can muster up. It hits me occasionally and seems to correlate with a sudden drop off in exercise/steps/activity. I am generally active and had a very active August and September. My pump settings have gradually been reducing my TDD to reduce the lows associated with those busy times. Now in October it’s been up and down. All it takes is two days in a row of reduced activity (such as sitting at my computer to do something or a long drive) and my post meal spikes are high (250+ three times a day) and long lasting. The treatment that semi-works for me is to correct the high BG with Affrezza. I use sequel twiist pump which uses Tidepool Loop algorithm. I felt like I had it as dialed in as possible back in August/September. Before I start fiddling (again) with the settings, I wanted to toss this query out…has anybody got some rules of thumb to adjust and prevent these bad days? Here is a plot of exercise days from Apple health app. I know the best answer is get the workout every day but sometimes that’s not possible. ![image](https://canada1.discourse-cdn.com/flex030/uploads/fudiabetes/original/2X/f/f1dbb0f28edd56db2346fe698c386b701b145a5c.jpeg) ---
**Author:** ![CarlosLuis](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/carlosluis/32/11389_2.png) [@CarlosLuis](https://forum.fudiabetes.org/u/CarlosLuis)\ **Post date:** [October 16, 2026, 11:18am UTC](https://forum.fudiabetes.org/t/sudden-onset-insulin-resistance/16426/2 "2026-10-16T11:18:06Z")
Ahh, @John58 , it appears you may have Type 1 with insulin resistance, formerly called double diabetes. Having autoimmune diabetes doesn’t mean one cannot inherit the multiple genetic variants that cause abnormal cellular insulin resistance. The correlation of physical activity and blood glucose levels is quite marked in Type 2 diabetes. Physical activity increases insulin sensitivity in everyone but much more in T2. I’m not saying this is true for you. If it is you might benefit from reducing daily carbohydrates and trying to get a 30 minute walk after long drives. ---
**Author:** ![CarlosLuis](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/carlosluis/32/11389_2.png) [@CarlosLuis](https://forum.fudiabetes.org/u/CarlosLuis)\ **Post date:** [October 16, 2026, 12:28pm UTC](https://forum.fudiabetes.org/t/sudden-onset-insulin-resistance/16426/3 "2026-10-16T12:28:17Z")
I want to add that it is my opinion that automatic functions on pumps cannot deal with varying insulin resistance. I use a tandem T:Slim with C-IQ. I’ve had a number of health issues that have increased insulin resistance either chemically (prednisone) or unable to get my regular daily exercise. When I was on high doses of prednisone, 40mg, I could stack corrections with no effect. I am not suggesting that anyone do this, but the only thing that worked was to use a 100u syringe with a 1/2’” needle and do an intramuscular injection of 10-12u in the deltoid muscle. Currently I am on the injured reserve list as far as cycling. I have not had to resort to the IM injections but I do override the suggested meal bolus and corrections. It would be nice if a pump could handle insulin resistance, but I don’t see that coming for people like me. ---
**Author:** ![bkh](https://avatars.discourse-cdn.com/v4/letter/b/da6949/32.png) [@bkh](https://forum.fudiabetes.org/u/bkh)\ **Post date:** [October 16, 2026, 2:02pm UTC](https://forum.fudiabetes.org/t/sudden-onset-insulin-resistance/16426/4 "2026-10-16T14:02:08Z")
> [@John58](#): > > I use sequel twiist pump which uses Tidepool Loop algorithm. I felt like I had it as dialed in as possible back in August/September. Before I start fiddling (again) with the settings, I wanted to toss this query out…has anybody got some rules of thumb to adjust and prevent these bad days? I’m not reluctant to make small changes to my pump settings. If my BG is trending too high after meals I’ll slightly change the I:C ratio to give more meal insulin. If my BG is tending to climb gradually, all by itself for no reason, I slightly increase the basal setting. If Loop’s corrections aren’t actually bringing down the BG I’ll slightly change the insulin sensitivity setting to get more insulin. Also, I’m pretty willing to taking manual extra doses of insulin when I see a BG rise unfolding faster than I like, rather than waiting for Loop to try to fix it, so this tends to mask any sudden insulin resistance or issues with insulin absorption at the cannula. ---
**Author:** ![CharlotteEngland](https://avatars.discourse-cdn.com/v4/letter/c/3d9bf3/32.png) [@CharlotteEngland](https://forum.fudiabetes.org/u/CharlotteEngland)\ **Post date:** [October 16, 2026, 2:09pm UTC](https://forum.fudiabetes.org/t/sudden-onset-insulin-resistance/16426/5 "2026-10-16T14:09:50Z")
Good call - I forget the fact i can adjust my insulin sensitivity - good one to use when dealing with rising progesterone i would imagine 🤔 will bear that in mind ---
**Author:** ![bkh](https://avatars.discourse-cdn.com/v4/letter/b/da6949/32.png) [@bkh](https://forum.fudiabetes.org/u/bkh)\ **Post date:** [October 16, 2026, 2:25pm UTC](https://forum.fudiabetes.org/t/sudden-onset-insulin-resistance/16426/6 "2026-10-16T14:25:08Z")
One thing to watch for is if you change the sensitivity too far, so it becomes too aggressive at dosing, that will cause the algorithm to make the BG oscillate — roller-coaster up down up down up down maybe even with increasing waves instead of decreasing waves. That’s a sign to back off a little. ---
**Author:** ![CatLady](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/catlady/32/36_2.png) [@CatLady](https://forum.fudiabetes.org/u/CatLady)\ **Post date:** [October 16, 2026, 4:49pm UTC](https://forum.fudiabetes.org/t/sudden-onset-insulin-resistance/16426/7 "2026-10-16T16:49:45Z")
> [@John58](#): > > seems to correlate with a sudden drop off in exercise/steps/activity. For me it’s stress and sometimes it feels like insulin AND activity don’t help to get my BG back into a normal range. I guess it’s because the cortisol response takes a long time to fade away. Trying to stay calm and not exacerbate the situation is so hard for me. ---
**Author:** ![John58](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/john58/32/147_2.png) [@John58](https://forum.fudiabetes.org/u/John58)\ **Post date:** [October 16, 2026, 5:24pm UTC](https://forum.fudiabetes.org/t/sudden-onset-insulin-resistance/16426/8 "2026-10-16T17:24:50Z")
Thanks for the ideas…I will keep fiddling/tweaking/adjusting. As I thought this through I remembered I typically used a seasonal basal change (10% more in fall/winter) over the years with Omnipod and MDI before that . I am going to try that first, perhaps it will help. ---
**Author:** ![TomH](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/tomh/32/9063_2.png) [@TomH](https://forum.fudiabetes.org/u/TomH)\ **Post date:** [October 16, 2026, 10:18pm UTC](https://forum.fudiabetes.org/t/sudden-onset-insulin-resistance/16426/9 "2026-10-16T22:18:25Z")
@John58 Thanks for asking about this. I suffer the same thing and have strived for a while to dial in an override or temp target without success. Example: I just got back from a “vacation river (bus) cruise” during which I usually walked significantly further each day due to excursions and ran a “vacation setting reducing my insulin intake/dosing including basal. It worked for the most part except my meals which were as well higher carb sorts though I was pretty good about deserts. I also accepted higher variances in BG because of the environs, more wine with dinner, etc. I’ll be interested in any comments from others! BTW, I use Omnipod Dash, G7, and DIY Trio as an AID.