# Study: glucose variability and inflammation

**URL:** <https://forum.fudiabetes.org/t/study-glucose-variability-and-inflammation/7688>\
**Category:** Type 1 & LADA\
**Created:** [June 12, 2019, 10:33pm UTC](https://forum.fudiabetes.org/t/study-glucose-variability-and-inflammation/7688 "2019-06-12T22:33:41Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![Jen](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/jen/32/4777_2.png) [@Jen](https://forum.fudiabetes.org/u/Jen)\
**Post date:** [June 12, 2019, 10:33pm UTC](https://forum.fudiabetes.org/t/study-glucose-variability-and-inflammation/7688/1 "2019-06-12T22:33:41Z")

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I know that the relevance of glucose variability in Type 1 diabetes has come up before, so I thought this study was interesting. I also find it interesting because my hsCRP has come back slightly high for years, and this makes me wonder if it’s linked to my diabetes.

> **[Glycemic variability predicts inflammation in adolescents with type 1 diabetes](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546213/)**
>
> Adolescents with type 1 diabetes (T1D) have increased risk of cardiovascular disease as well as elevations in biomarkers of systemic inflammation, plasma protein oxidation and vascular endothelial injury. It is unclear whether hyperglycemia itself,...

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**Author:** ![TiaG](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/tiag/32/594_2.png) [@TiaG](https://forum.fudiabetes.org/u/TiaG)\
**Post date:** [June 13, 2019, 1:58am UTC](https://forum.fudiabetes.org/t/study-glucose-variability-and-inflammation/7688/2 "2019-06-13T01:58:18Z")

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yeah but look at Figure 1. The scatter on that data… is quite significant. And it seems they didn’t find a direct linear relationship. Instead they took the _log_ of C-reactive protein, which I don’t understand the logic of (there might be some there, but I just don’t know what it is.)

Then you can also add in the usual caveats: Small study, these kids had an average A1C of 8.3, the SD for NONE of the participants is below 50 (so we’re talking pretty bad control), fasting glucose of 160 mg/DL, etc. etc. etc.

I think it still doesn’t answer the question of which is better: an A1C of 6.5 with a standard deviation of 50, or an A1C of 7.5 with a standard deviation of 30.