# Starting GLP1 **URL:** \ **Category:** Type 1 & LADA\ **Created:** [October 2, 2025, 5:28pm UTC](https://forum.fudiabetes.org/t/starting-glp1/15476 "2025-10-02T17:28:08Z")\ **Posts on this page:** 6\ **Page:** 1
**Author:** ![mstan](https://avatars.discourse-cdn.com/v4/letter/m/5f8ce5/32.png) [@mstan](https://forum.fudiabetes.org/u/mstan)\ **Post date:** [October 2, 2025, 5:28pm UTC](https://forum.fudiabetes.org/t/starting-glp1/15476/1 "2025-10-02T17:28:08Z")
I am about to start using wegovy…a bit apprehensive. Any tips? ---
**Author:** ![Eric](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/eric/32/9209_2.png) [@Eric](https://forum.fudiabetes.org/u/Eric)\ **Post date:** [October 3, 2025, 3:39pm UTC](https://forum.fudiabetes.org/t/starting-glp1/15476/2 "2025-10-03T15:39:01Z")
Hi @mstan, There is a good thread with comments here: > [@Glp1 agonists Ozempic® and Wegovy® semaglutide](https://forum.fudiabetes.org/t/glp1-agonists-ozempic-and-wegovy-semaglutide/14875): > > Saw a story on CBS this morning about a woman who has a family history of T2DM and trouble losing weight. Her doctor prescribed her a GLP1 agonist. Everything was fine. She lost weight and cravings for food Out of the blue she passed out. Husband rushed her to the hospital, at some point her daughter was informed that her Mom might not make it. She was stabilized and it was determined her colon had died. They did a colonectomy and she now has a colonostomy. I don’t mean to scare anyone. It wa… ---
**Author:** ![CarlosLuis](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/carlosluis/32/11389_2.png) [@CarlosLuis](https://forum.fudiabetes.org/u/CarlosLuis)\ **Post date:** [October 3, 2025, 3:50pm UTC](https://forum.fudiabetes.org/t/starting-glp1/15476/3 "2025-10-03T15:50:34Z")
Glucagon-like peptide 1 (GLP-1) agonists are medications approved for treatment of diabetes that recently have also been used off label for weight loss.[1](https://jamanetwork.com/journals/jama/fullarticle/2810542#jld230072r1) Studies have found increased risks of gastrointestinal adverse events (biliary disease,[2](https://jamanetwork.com/journals/jama/fullarticle/2810542#jld230072r2) pancreatitis,[3](https://jamanetwork.com/journals/jama/fullarticle/2810542#jld230072r3) **bowel obstruction** ,[4](https://jamanetwork.com/journals/jama/fullarticle/2810542#jld230072r4) and gastroparesis[5](https://jamanetwork.com/journals/jama/fullarticle/2810542#jld230072r5)) in patients with diabetes.[2](https://jamanetwork.com/journals/jama/fullarticle/2810542#jld230072r2)-[5](https://jamanetwork.com/journals/jama/fullarticle/2810542#jld230072r2)Because such patients have higher baseline risk for gastrointestinal adverse events, risk in patients taking these drugs for other indications may differ. Randomized trials examining efficacy of GLP-1 agonists for weight loss were not designed to capture these events[2](https://jamanetwork.com/journals/jama/fullarticle/2810542#jld230072r2) due to small sample sizes and short follow-up. We examined gastrointestinal adverse events associated with GLP-1 agonists used for weight loss in a clinical setting. [https://jamanetwork.com/journals/jama/fullarticle/2810542](https://jamanetwork.com/journals/jama/fullarticle/2810542) Bowel obstruction can lead to the loss of blood supply and colon death. ---
**Author:** ![allison](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/allison/32/10718_2.png) [@allison](https://forum.fudiabetes.org/u/allison)\ **Post date:** [October 3, 2025, 5:34pm UTC](https://forum.fudiabetes.org/t/starting-glp1/15476/4 "2025-10-03T17:34:13Z")
As a type 1 who has been on GLP-1s for over a decade, just be very cautious with your blood sugar levels. Do you have a CGM? I’ve found that my insulin needs decreased DRASTICALLY. My dose just went up so that threw a wrench into things and now I’m having to figure out what my ratios are for the first couple of days after I take it vs. when it’s starting to wear off after a week. It’s been so worth it though - my A1cs are better and I’ve lost a lot of weight. ---
**Author:** ![jbowler](https://avatars.discourse-cdn.com/v4/letter/j/e274bd/32.png) [@jbowler](https://forum.fudiabetes.org/u/jbowler)\ **Post date:** [October 3, 2025, 10:52pm UTC](https://forum.fudiabetes.org/t/starting-glp1/15476/5 "2025-10-03T22:52:22Z")
> [@allison](#): > > I’ve found that my insulin needs decreased DRASTICALLY. That can happen other ways; it’s something we all need to think about regardless of whether we use GLP-1s. I’ve found quite consistently that my insulin sensitivity spiked after a day doing hard labour. The next day I go low continuously simply because my basal is too high after the spike. On a slightly lesser scale my sensitivity goes up in spring, when I start jumping around, and down around now, when I stop. I used to shift my basal by around 20% to cope with those changes, but these days I just keep it at “summer” and like my AIDS handle the BG overage. I regard GLP-1s as incredibly important for us. I suspect in the confrontational environment we live in simple use for weight loss will get dissed out of existence but for us I’m pretty damn sure the scientific reports of the results will be spectacular in a few years time. I’m certainly with you on the CGM but then I think everyone should have a CGM. Would certainly help a few non-Ds I’ve encountered 🙂 ---
**Author:** ![allison](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/allison/32/10718_2.png) [@allison](https://forum.fudiabetes.org/u/allison)\ **Post date:** [October 3, 2025, 11:13pm UTC](https://forum.fudiabetes.org/t/starting-glp1/15476/6 "2025-10-03T23:13:57Z")
Well, I’ve been diabetic for 30 years so I know what’s related to the medications I’m on and what’s not. There are so many factors that affect blood sugar, so I’m pretty tuned in to what causes mine to change. When I increased my ozempic, it was a significant change that I could tell was directly related to the medicine. It’s been a great help to me and obviously lots of other diabetics (and non-diabetics). And yes, everyone should have a CGM. Life with diabetes is much more predictable that way.