Should I take statins?

I’m doing a controlled experiment, or as close to it as possible.

Things like this are hard for me because I live in several different environments— at work on a ship, at home, traveling, etc.

I decided that the most controlled environment for an experiment is at work on a ship. I stopped taking crestor for about 10 days— and recorded my cgm data for the last week of it. Today I started taking it again… I’ll only be on the ship for about 5 more days, but I should have some pretty valid data to compare by then including total insulin usage, average BG, standard of deviation, and basal/ bolus ratio. Will see if I can observe any trends.

I had discussed this with my doc, and she said that pravastatin is an option that has less risks regarding upsetting the blood sugar apple cart than crestor (rosuvastatin) We’ll see what the data shows

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Interesting results

Off crestor:
Average glucose 125
Standard deviation 26
Average daily insulin total 37.9u
Operating pump in manual mode 19% of time

On crestor
Average glucose 130
Standard deviation 29
Average daily insulin total 44.4u
Operating pump in manual mode 37% of time — indicative of putting more work into managing blood sugar—

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I wanted to update this…

I had a couple evolutions that are noteworthy. Taking crestor, my blood sugar got more and more difficult to control. I didn’t make the correlation immediately… but eventually I did… and I mentioned it to my doctor and they switched me to pravastatin. I noticed an improvement.

Over last summer while working away from home I ran out of pravastatin, and asked my wife to mail me more… after about a week —- she accidentally mailed me the crestor (rosuvastatin)…. It was what I had so I started taking it again and my bg control suffered… after a couple more weeks I got the pravastatin again and it improved somewhat, but not as much as I’d enjoyed while not taking either

so I talked to my doc again, and told her I’d had a couple natural experiments and was now absolutely convinced that statins were making my bg management more difficult. And therefore I’d stopped taking them until we re-chart the course and discuss the pros/cons

She heard me, acknowledged me, said she’d talk to her clinical pharmacist partner to see if there were better options…. Got back to me after a couple days with the suggestion of the minimum dose of “pitavistatin”. Which I’ve been taking for several weeks now with no complaints

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@Sam Thanks for the post! I wasn’t aware the different statins would have that much impact! I wonder if my atorvastatin (used as a precaution for years!) has significant impact on my own use. I’ll have to discuss with my Endo at next appt (not for six months due to otherwise good control). Do you or any others have input on what works best for you/them?

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Be really cautious about simply stopping a statin. It can result in a very rapid onset of several problems. If you’re on a statin, don’t simply stop taking it, even in the name of science. A very rapid reversal of the statin effects can occur, causing a rapid buildup and blockage of blood vessels, etc. It can lead to a heart attack or stroke.

I take atorvastain, along with metformin. I take 1000 mg Metformin twice daily, and 40 mg atorvastatin in a pill once daily, along with a plethora of vitamins and supplements, fish oil, turmeric, etc. My cholesterol values are all normal presently, but will likely skew quickly should I simply stop taking the medication. At most, one should make a phased withdrawal, and only in coordination with one’s physician. Even changing the time of day significantly can have some effect, but quitting cold turkey, once on a statin, is unwise.

If stopping a medication to test the effects on glucose, etc, then one needs to be off the medication for a significant enough time to be medically free of the medication, to get an actual baseline. Otherwise, all you test is a transitional phase in which your body begins immediately increasing cholesterol and seeking balance…but you’d have to be off it for a month or two before getting your data….because of course you’ll see fluctuations in the transition. Readings taken immediately after quitting the statin are not valid indicators of what you should expect once you’re completely finished, it’s out of your system and your bodily functions have stabilized.

My doctor had suggested going to a half-dose on everything, last year, and I dutifully cut the pills in half with a cutter and re-distributed everything. I keep fairly careful records, and went on half meds for a month. I was considerably less stable during that time, and returned to the full medication. I was more stable again on the full meds, with better numbers. I’m not anxious to do that again.

When I started on the atorvastatin, my blood sugar was high, and my cholesterol was high. I needed to lose weight. I lost 60 lbs, and my cholesterol values dropped so low that the doctor said he’d never seen anything so rapid or drastic. He said I needed to bring it back up…too low. The atorvastatin continues to be prescribed in conjunction with the metformin, and I eat peanut butter and fish and take fish oil regularly; all the numbers are back low to mid-range, with good cholesterol at the bottom of the range. The meds are cheap, I’m stable while on them, and I have no ill side effects, so won’t be quick to stop them, or alter the dosage.

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I understand all of that. But none of it invalidates my experience or observation of which statins effect my blood sugar control ranging from a lot, to an intermediate amount, to less so

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Thank you, good to know. I’ve only taken pravastatin and haven’t noticed an issue.

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You could try the new LDL-C equation, the one that the NIH has recommended since 2021:

https://www.medcentral.com/calculators/cardiology/sampson-equation-for-low-density-lipoprotein-ldl-c

The calculator is correct (the new equation) however the equation they give is the old equation (the Friedewalde equation) but I notice that my Asante lab results were still using the old equation in 2024. Here’s Stanford’s description of the change, including the real (Sampson) equation:

Fasting is not required to get the right result. The main control on LDL is saturated fat intake vs unsaturated fat intake. Statins mess with fat metabolism so that’s the most obvious explanation of why they change the balance. They are also associated with an increased risk of diabetes:

There’s various stuff in that review paper.

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