# Running a marathon! :D

**URL:** https://forum.fudiabetes.org/t/running-a-marathon-d/8963
**Category:** Sports & Exercise
**Created:** [December 24, 2019, 5:33pm UTC](https://forum.fudiabetes.org/t/running-a-marathon-d/8963 "2019-12-24T17:33:21Z")
**Posts on this page:** 1
**Showing post:** 107

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### Author: ![Eric](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/eric/32/9209_2.png) [@Eric](https://forum.fudiabetes.org/u/Eric)
#### Post date: [March 29, 2020, 5:20pm UTC](https://forum.fudiabetes.org/t/running-a-marathon-d/8963/107 "2020-03-29T17:20:55Z")

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> [@LarissaW](#):
>
> Did 18 yesterday ✅ **and my I:C ratio ended up at 1:3,536 on the run**

Welcome to infinity!!

Kinda neat, because eventually everything we discuss on FUD becomes relevant!

> [@How exercise increases the effect of insulin and carb usage](https://forum.fudiabetes.org/t/how-exercise-increases-the-effect-of-insulin-and-carb-usage/3857/1):
>
> 1. **Exercise can cause glucose uptake independent of insulin.** Exercise of sufficient intensity promotes the uptake of glucose by muscles without insulin. The body is clever - exercising muscles need more fuel, so there needs to be a way to provide more fuel to them. This can happen without insulin, but only at sufficient intensity. This is where it kind of gets tricky, but basically there is one important note at the bottom that is the one thing worth hanging on to.
> 
> Not to get too deep in the weeds with it, but exercise increases uptake of glucose through what is called a “contraction mediated pathway”.
> 
> _Adenylate kinase (ADK) converts 2 adenosine diphosphate (ADP) molecules into 1 adenosine triphosphate (ATP) molecule and 1 adenosine monophosphate (AMP) molecule. The ATP is hydrolyzed for energy, and the AMP attracts 5’-adenosine monophosphate-activated protein kinase (AMPK). AMPK acts in a way similar to how protein kinase B (Akt) recruits TBC1D1 (detailed in this post - [Biochemistry - what does insulin actually do?!](https://forum.fudiabetes.org/t/biochemistry-what-does-insulin-actually-do/3809)), which releases GLUT4 to the cell surface and allows glucose uptake. Additionally, calcium ions released from the sarcoplasmic reticulum during muscle contraction also promotes GLUT4. Other pathways include ROS signaling, and nitric oxide signaling._
> 
> Bottom line, (the important part) **there are redundant and overlapping pathways for glucose uptake that occur during muscle contraction (exercise) that do not rely on insulin!**

Discussion from almost 2 years ago, April of 2018!

Full text in this ⬇ thread.

[how-exercise-increases-the-effect-of-insulin-and-carb-usage](https://forum.fudiabetes.org/t/how-exercise-increases-the-effect-of-insulin-and-carb-usage/3857)

It’s really cool to see that - no insulin, just keep needing carbs over and over! How awesome, right?!?

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> [@LarissaW](#):
>
> @Eric - did you want to tell everyone what you’re working on???

I am working on getting **you** to **both** lines - the start and the finish. 😉

[![](https://img.youtube.com/vi/5ZtbCOpx8Sk/hqdefault.jpg "Tootsie Pops - "How Many Licks?" (Commercial, 1982)🦉") ](https://www.youtube.com/watch?v=5ZtbCOpx8Sk)

Like it says in the commercial, “_…the world may never know…_”

But that’s okay, because we will know.

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