# Reducing your a1c too quickly

**URL:** https://forum.fudiabetes.org/t/reducing-your-a1c-too-quickly/2320
**Category:** Complications & More
**Tags:** retinopathy
**Created:** [October 11, 2017, 12:27am UTC](https://forum.fudiabetes.org/t/reducing-your-a1c-too-quickly/2320 "2017-10-11T00:27:24Z")
**Posts on this page:** 1
**Showing post:** 21

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### Author: ![Eric](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/eric/32/9209_2.png) [@Eric](https://forum.fudiabetes.org/u/Eric)
#### Post date: [October 11, 2017, 3:42pm UTC](https://forum.fudiabetes.org/t/reducing-your-a1c-too-quickly/2320/21 "2017-10-11T15:42:44Z")

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> [@Beacher](#):
>
> There is some evidence (and plenty of observation) that lowering A1c – that is, in general, tightening control – too rapidly can result in a period of proliferative retinopathy,

On the referenced study I don’t understand the conclusion because they make this statement in the **results** section:

`We found no evidence to suggest that more gradual reduction of glycemia might be associated with less risk of early worsening.`

Maybe I am not understanding the sentence. The words “no”, “more”, “less”, and “early” in the same sentence. Anything more than 3 adjectives and adverbs in a single sentence and I am lost. 😄

> **[Early worsening of diabetic retinopathy in the Diabetes Control and...](https://pubmed.ncbi.nlm.nih.gov/9682700/)**
>
> In the DCCT, the long-term benefits of intensive insulin treatment greatly outweighed the risks of early worsening. Although no case of early worsening was associated with serious visual loss, our results are consistent with previous reports of...

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