# Not a cure, but seems promising
**URL:** https://forum.fudiabetes.org/t/not-a-cure-but-seems-promising/15349
**Category:** D-News
**Tags:** research, type-1
**Created:** [July 10, 2025, 10:39am UTC](https://forum.fudiabetes.org/t/not-a-cure-but-seems-promising/15349 "2025-07-10T10:39:04Z")
**Posts on this page:** 9
**Page:** 1
### Author:  [@Mariethm](https://forum.fudiabetes.org/u/Mariethm)
#### Post date: [July 10, 2025, 10:39am UTC](https://forum.fudiabetes.org/t/not-a-cure-but-seems-promising/15349/1 "2025-07-10T10:39:04Z")
> **[First UK Patients Receive Diabetes Drug That Delays Symptoms by Years](https://www.sciencealert.com/first-uk-patients-receive-diabetes-drug-that-delays-symptoms-by-years)**
>
> For more than a century, type 1 diabetes has meant one thing: a lifetime administering insulin.
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### Author:  [@CarlosLuis](https://forum.fudiabetes.org/u/CarlosLuis)
#### Post date: [July 10, 2025, 11:52am UTC](https://forum.fudiabetes.org/t/not-a-cure-but-seems-promising/15349/2 "2025-07-10T11:52:04Z")
Thisis a really interesting development. It might be the pathway to a cure using an individuals stem cells to grow new Beta cells in conjunction with this treatment. That would be closer to a cure without the need for immunosuppressant drugs,
## HERE’S WHAT YOU CAN EXPECT FROM TREATMENT WITH TZIELD:
### TZIELD is an **intravenous (IV) infusion.**
This means it’s given through a needle in your arm. TZIELD infusions are given once a day, for 14 days in a row, and take at least 30 minutes plus setup and monitoring time. TZIELD is a one-time treatment.
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### Author:  [@jbowler](https://forum.fudiabetes.org/u/jbowler)
#### Post date: [July 14, 2025, 11:48pm UTC](https://forum.fudiabetes.org/t/not-a-cure-but-seems-promising/15349/3 "2025-07-14T23:48:37Z")
It looks like a whole load of AI generated stuff off the original BBC News post:
> **[Devon mother treated with game-changing diabetes drug](https://www.bbc.com/news/articles/cgq74z3701eo)**
>
> Teplizumab, which is not routinely available in the UK, works by reprogramming the immune system.
Then here, from February:
> **[Kings Norton teen in Birmingham receives game-changing diabetes drug](https://www.bbc.com/news/articles/c4gx1l23r15o)**
>
> Sam,14, is offered Teplizumab in Birmingham, a new treatment to delay the onset of the condition.
So back to 2022 (in the US this time):
> **[Game-changing type 1 diabetes drug approved in US](https://www.bbc.com/news/health-63663338)**
>
> It is the first drug to be approved that delays the onset of the condition.
So it’s been available in the US since 2022; it’s a “monoclonal antibody”.
The curious thing about it is that it is being marketed as a delaying tactic; delaying the onset of T1 by two or three years. Yet it seems that for many people the onset is much slower than that anyway, particularly LADA. My cynical brain thinks that they are just selling statistics.
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### Author:  [@JessicaD](https://forum.fudiabetes.org/u/JessicaD)
#### Post date: [July 18, 2025, 1:17am UTC](https://forum.fudiabetes.org/t/not-a-cure-but-seems-promising/15349/4 "2025-07-18T01:17:04Z")
The daughter of one of my diabetic friends, who has had T1 antibodies for a number of years, was recently treated with TZield. It was insanely expensive, but they did get their insurance to cover it. Shortly after the treatment, she hit the point where she needed to start insulin (a small amount of basal), which is not what they hoped for, but they are hoping that this will allow her to remain on just the small dose of basal for a long time. Fingers crossed.
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### Author:  [@jbowler](https://forum.fudiabetes.org/u/jbowler)
#### Post date: [July 18, 2025, 9:51pm UTC](https://forum.fudiabetes.org/t/not-a-cure-but-seems-promising/15349/5 "2025-07-18T21:51:47Z")
> [@JessicaD](#):
>
> TZield
Here’s a summary of the UK regulatory authorities approach so far:
> **[Teplizumab](https://www.diabetes.org.uk/about-diabetes/looking-after-diabetes/treatments/tablets-and-medication/teplizumab)**
>
> Teplizumab is a drug that can treat people found to be in the early stages of
It was licensed in the US in 2022 but then things are licensed in the US regardless of cost; most of the process seems to involve maxims along the lines of, “Does it kill the patient, does it use illegal drugs.”
The UK approach is cost based, which means that the proponents will have to demonstrate a statistically significant result in at least one area (like slowing down T1 in LADA). From the [diabetes.uk](http://diabetes.uk) summary it seems like a possible application is your friend; slowing down the loss of beta cells might be worth the insane expense.
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### Author:  [@SarahFreq](https://forum.fudiabetes.org/u/SarahFreq)
#### Post date: [September 9, 2025, 6:37pm UTC](https://forum.fudiabetes.org/t/not-a-cure-but-seems-promising/15349/6 "2025-09-09T18:37:42Z")
This is another advancement in science. It’s in the super beginning stages, so no one have any hope yet. It’s editing stem cells to bypass rejection from the body. Only 1 person has been tested & been successful.
[https://www.nature.com/articles/d41586-025-02802-5?utm\_source=Live+Audience&utm\_campaign=fc8cf5e4b1-nature-briefing-daily-20250909&utm\_medium=email&utm\_term=0\_-33f35e09ea-499595662](https://www.nature.com/articles/d41586-025-02802-5?utm_source=Live+Audience&utm_campaign=fc8cf5e4b1-nature-briefing-daily-20250909&utm_medium=email&utm_term=0_-33f35e09ea-499595662)
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### Author:  [@Boerenkool](https://forum.fudiabetes.org/u/Boerenkool)
#### Post date: [September 12, 2025, 6:36pm UTC](https://forum.fudiabetes.org/t/not-a-cure-but-seems-promising/15349/7 "2025-09-12T18:36:19Z")
Thanks for the link to Nature’s discussion of this study! Scientific American had an article about that too, which we were discussing over here:
> [@First islet cell transplant without immunosuppression](https://forum.fudiabetes.org/t/first-islet-cell-transplant-without-immunosuppression/15441):
>
> A very interesting study by a Swedish-American collaboration of researchers was published recently. The focus of this study was islet transplantation without immunosuppression. This is supposedly the first time ever a type 1 diabetes patient successfully received an islet cell transplant without the need for immunosuppression. Instead the donor cells were genetically modified using CRISPR to evade the immune system. This is not a cure yet. The title of this Scientific American article is a bit …
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### Author:  [@SarahFreq](https://forum.fudiabetes.org/u/SarahFreq)
#### Post date: [September 12, 2025, 7:06pm UTC](https://forum.fudiabetes.org/t/not-a-cure-but-seems-promising/15349/8 "2025-09-12T19:06:30Z")
Awesome! Sorry I put that article in the wrong spot. I’m glad more media outlets are discussing this.
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### Author:  [@Boerenkool](https://forum.fudiabetes.org/u/Boerenkool)
#### Post date: [September 12, 2025, 8:24pm UTC](https://forum.fudiabetes.org/t/not-a-cure-but-seems-promising/15349/9 "2025-09-12T20:24:22Z")
No worries, there’s no way to keep track of all topics discussed here! 😄