# Issues with insulin dosing when combined with SGLT 2 inhibitors
**URL:** https://forum.fudiabetes.org/t/issues-with-insulin-dosing-when-combined-with-sglt-2-inhibitors/13903
**Category:** Type 2 & MODY
**Tags:** insulin, jardiance, farxiga
**Created:** [June 17, 2023, 6:14pm UTC](https://forum.fudiabetes.org/t/issues-with-insulin-dosing-when-combined-with-sglt-2-inhibitors/13903 "2023-06-17T18:14:03Z")
**Posts on this page:** 3
**Page:** 1
### Author:  [@CarlosLuis](https://forum.fudiabetes.org/u/CarlosLuis)
#### Post date: [June 17, 2023, 6:14pm UTC](https://forum.fudiabetes.org/t/issues-with-insulin-dosing-when-combined-with-sglt-2-inhibitors/13903/1 "2023-06-17T18:14:03Z")
I’ve been having troubling trends with rising creatinine in urine. My endocrinologist suggested SGLT 2 inhibitors which have a protective effect on the kidneys as well as lowering the glucose threshold so the kidneys will excrete glucose at lower levels than \>180mg/dl.
I have an appointment with a nephrologist in July, but endo gave me 21 days of sample Farxiga. I will start that Monday.
My question is mostly should I reduce basal and carb factor. Anyone with experience with using this drug class with or without insulin would be helpful. Thanks
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### Author:  [@CatLady](https://forum.fudiabetes.org/u/CatLady)
#### Post date: [June 19, 2023, 4:17pm UTC](https://forum.fudiabetes.org/t/issues-with-insulin-dosing-when-combined-with-sglt-2-inhibitors/13903/2 "2023-06-19T16:17:55Z")
> **[Do GLP-1s and SGLT2s Affect Insulin Use, and Do They Cause Hypoglycemia? -...](https://tcoyd.org/2021/08/how-do-glp-1s-and-sglt2s-affect-insulin-use-and-hypoglycemia/)**
>
> Dr. Edelman clarifies how SGLT2s and GLP-1s affect insulin use, and whether or not they cause hypoglycemia.
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### Author:  [@CarlosLuis](https://forum.fudiabetes.org/u/CarlosLuis)
#### Post date: [June 19, 2023, 4:55pm UTC](https://forum.fudiabetes.org/t/issues-with-insulin-dosing-when-combined-with-sglt-2-inhibitors/13903/3 "2023-06-19T16:55:32Z")
Thank you, @CatLady I took the first dose of Farxiga last night. I am keeping a close eye on BG levels and making sure to drink lots of water. From one study I read recently SGLT2 inhibitors lower the threshold for the kidneys to excrete glucose is around 20mg/dl. It seems to me that keeping tight control will limit glucose in urine and the tendency to UTIs and yeast issues.
I will update when I have some real data on TDD, both basal and bolus, and other changes such as glucose, albumen and creatinine in urine. I just ordered some test strips that do 14 different urine test.
I can’t help it. I am a compulsive data collector and analyst.