# Insulin not working how we thought it did

**URL:** <https://forum.fudiabetes.org/t/insulin-not-working-how-we-thought-it-did/13658>\
**Category:** T1 Research\
**Tags:** insulin, type-1\
**Created:** [March 11, 2023, 1:25am UTC](https://forum.fudiabetes.org/t/insulin-not-working-how-we-thought-it-did/13658 "2023-03-11T01:25:22Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![bwschulz](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/bwschulz/32/8869_2.png) [@bwschulz](https://forum.fudiabetes.org/u/bwschulz)\
**Post date:** [March 11, 2023, 1:25am UTC](https://forum.fudiabetes.org/t/insulin-not-working-how-we-thought-it-did/13658/1 "2023-03-11T01:25:22Z")

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> **["We have miscalculated for decades – half of an insulin dose may not work as...](https://news.ku.dk/all_news/2023/02/we-have-miscalculated-for-decades--half-of-an-insulin-dose-may-not-work-as-expected/)**
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> New research suggests that a large portion of a diabetic's insulin dose is unlikely to work as expected. University of Copenhagen researchers have discovered that we have miscalculated insulin behavior for many years. The discovery provides a tool...

TLDR: Much of the insulin that diabetics currently put into their bodies may not actually be getting absorbed as expected. While the researchers emphasize that this is not outright dangerous for patients, it does show that there is great potential for the development of more precise medications.

Full paper is here if you’re into that sort of thing: [Enhanced hexamerization of insulin via assembly pathway rerouting revealed by single particle studies | Communications Biology](https://www.nature.com/articles/s42003-022-04386-6)

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**Author:** ![TomH](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/tomh/32/9063_2.png) [@TomH](https://forum.fudiabetes.org/u/TomH)\
**Post date:** [March 12, 2023, 9:38pm UTC](https://forum.fudiabetes.org/t/insulin-not-working-how-we-thought-it-did/13658/2 "2023-03-12T21:38:12Z")

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@bwschulz Thanks for posting this, interesting read with potential for future insulins…possibly other drugs to based on how they “observed” the mechanisms of formulations.