# \[FIRSTS\] - Used Glucagon tonight (09012019) **URL:** \ **Category:** Child\ **Created:** [September 1, 2019, 2:56am UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228 "2019-09-01T02:56:20Z")\ **Posts on this page:** 19\ **Page:** 2
**Author:** ![CatLady](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/catlady/32/36_2.png) [@CatLady](https://forum.fudiabetes.org/u/CatLady)\ **Post date:** [September 1, 2019, 2:48pm UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/21 "2019-09-01T14:48:16Z")
So glad for this news. Hope Liam feels a whole lot better today!! ---
**Author:** ![ClaudnDaye](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/claudndaye/32/5_2.png) [@ClaudnDaye](https://forum.fudiabetes.org/u/ClaudnDaye)\ **Post date:** [September 1, 2019, 3:04pm UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/22 "2019-09-01T15:04:55Z")
Is the refrigerated shelf life (after being mixed), indeed, just 24 hours? Just want to make sure before I throw it out this evening. ---
**Author:** ![Thomas](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/thomas/32/1719_2.png) [@Thomas](https://forum.fudiabetes.org/u/Thomas)\ **Post date:** [September 1, 2019, 3:09pm UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/23 "2019-09-01T15:09:57Z")
> [@ClaudnDaye](#): > > Is the refrigerated shelf life (after being mixed), indeed, just 24 hours? If you happen to have a willing guinea pig around (which I personally do not include my child in but… willing adult??) it could be an interesting thing to see for yourself. ---
**Author:** ![ClaudnDaye](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/claudndaye/32/5_2.png) [@ClaudnDaye](https://forum.fudiabetes.org/u/ClaudnDaye)\ **Post date:** [September 1, 2019, 3:11pm UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/24 "2019-09-01T15:11:48Z")
I’m sure this is something the FUD guinea pig (@Eric) has already tested many times. 😆 To be on the safe side, I’ll just throw it out, but it would still be interesting to know. I guess the reason to throw it out would be that the mix just goes bad after 24 hours of being mixed, but I can’t find anything specific as to “why” it’s important to throw it away after 24 hours. If it’s just a “the FDA has only approved 24 hours” thing then that doesn’t hold much water since we are constantly using things longer and in more extreme circumstances than have been approved by the FDA. Eric? ---
**Author:** ![Eric](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/eric/32/9209_2.png) [@Eric](https://forum.fudiabetes.org/u/Eric)\ **Post date:** [September 1, 2019, 4:02pm UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/25 "2019-09-01T16:02:43Z")
> [@ClaudnDaye](#): > > Is the refrigerated shelf life (after being mixed), indeed, just 24 hours? Just want to make sure before I throw it out this evening I did the expired glucagon test and on this thread below, I did a demo where I used it **5 days later** and it worked fine! Check out this post: > [@Expired glucagon](https://forum.fudiabetes.org/t/expired-glucagon/1417/39): > > A little update on this. I mixed the expired glucagon 5 days ago. It worked fine then. I tested it a day later, and it still worked. So 5 days after mixing the glucagon, I did another test today. The same mini-dose I did before, 25 units (just 1/4 of the entire dosage you get in a glucagon kit), and it brought me up 89 points in just 30 minutes. That’s pretty consistent with day 2: 2nd day after mixing: 106 points in 35 minutes 5th day after mixing: 89 points in 30 minutes Anyway, the poi… ---
**Author:** ![ClaudnDaye](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/claudndaye/32/5_2.png) [@ClaudnDaye](https://forum.fudiabetes.org/u/ClaudnDaye)\ **Post date:** [September 1, 2019, 4:05pm UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/26 "2019-09-01T16:05:38Z")
haha. I should use SEARCH more than I do! I even thanked you for that post and added your :guinea_pig: image! 😛 Thanks, Eric. I’m just wondering if there is anything negative about using it…like are the mixed chemicals possibly going to make him sick if I were to use beyond the 24 hours. Did you feel any different using it (nausea, etc.,?) It sucks that you get so little of this so when you use it really is limited. Can’t wait for glucagon with longer shelf life to be a feasible thing. ---
**Author:** ![Jen](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/jen/32/4777_2.png) [@Jen](https://forum.fudiabetes.org/u/Jen)\ **Post date:** [September 1, 2019, 4:14pm UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/27 "2019-09-01T16:14:34Z")
I’m so glad the mini-dose glucagon worked well. > [@ClaudnDaye](#): > > If it’s just a “the FDA has only approved 24 hours” thing then that doesn’t hold much water since we are constantly using things longer and in more extreme circumstances than have been approved by the FDA. Technically, I don’t believe the FDA or any other country’s health authority has approved glucagon for mini-dose at all, so it’s all off-label anyway. Here in Canada, CDEs and endos _do_ officially recommend it, but it sounds like that may not be the case in the US from some posts I’ve read. I have no data to add as I’ve always just thrown it out after 24 hours. Hopefully the stable pens designed specifically for mini-dose glucagon will come along soon. ---
**Author:** ![Eric](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/eric/32/9209_2.png) [@Eric](https://forum.fudiabetes.org/u/Eric)\ **Post date:** [September 1, 2019, 4:19pm UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/28 "2019-09-01T16:19:19Z")
> [@ClaudnDaye](#): > > I’m just wondering if there is anything negative about using it…like are the mixed chemicals possibly going to make him sick if I were to use beyond the two days. Did you feel any different using it (nausea, etc.,?) It’s fine. I think the thing to do is - don’t make a plan for using it X days from now. I mean, don’t plan to make him low for the purpose of testing it. Just hang on to it. If you need it at some point in the next few days, then try it. Just a little bit. Draw it up with an insulin syringe, just a small amount like 10 units. Watch the magic. Instead of a 50 point jump, you could see a 20 point jump which might be just perfect. This is why I am very interested in the shelf-stable glucagon becoming available. Once that happens, the next thing is that pumps could use it for lows. Imagine how much more effective it would be to treat a low if your pump spit out a few units of glucagon, instead of stopping your basal for 30 minutes or an hour and waiting for your BG to eventually come up! Much faster! That’s why we need the shelf-stable stuff. It opens up an entirely new avenue of treatment. And that’s why the nasal glucagon to me is a step backward, because it potentially reduces the interest and excitement in the development of something that would eventually be much more useful… ---
**Author:** ![TiaG](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/tiag/32/594_2.png) [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Post date:** [September 2, 2019, 12:52am UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/29 "2019-09-02T00:52:16Z")
you can likely use it up to 72 hours in the fridge. That’s what our endo says anyways. I know people (older nurses who have had D for years) who use mini-glucagon for weeks, until they use it up. But I wouldn’t recommend that; it gets gradually less potent over time as it denatures and it forms amyloid fibrils when it denatures. Probably harmless but I’m not keen on using it personally. ---
**Author:** ![TiaG](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/tiag/32/594_2.png) [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Post date:** [September 2, 2019, 12:58am UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/30 "2019-09-02T00:58:54Z")
Here are some studies on glucagon denaturing: > **[Structural Transitions and Interactions in the Early Stages of Human Glucagon...](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336368/)** > > A mechanistic understanding of the intermolecular interactions and structural changes during fibrillation is crucial for the design of safe and efficacious glucagon formulations. Amide hydrogen/deuterium exchange with mass spectrometric analysis was... > **[Glucagon: Physiology and Pharmacotherapy: The Nature of Amyloid-like Glucagon...](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005045/)** > > Protein aggregation and formation of amyloid fibrils is a phenomenon usually associated with proteotoxicity and degenerative diseases, such as type 2 diabetes, Alzheimer’s disease, and prion diseases. However, several protein and peptide hormones ... ---
**Author:** ![ardipa](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/ardipa/32/3570_2.png) [@ardipa](https://forum.fudiabetes.org/u/ardipa)\ **Post date:** [September 2, 2019, 3:08pm UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/31 "2019-09-02T15:08:43Z")
![baqsimi%202](https://canada1.discourse-cdn.com/flex030/uploads/fudiabetes/original/2X/4/410be007d6937983beb952d89dddb018b4f3c925.jpeg) Eric, how can we micro-dose BAQSIMI? At $280 a pop, ---
**Author:** ![Eric](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/eric/32/9209_2.png) [@Eric](https://forum.fudiabetes.org/u/Eric)\ **Post date:** [September 2, 2019, 4:03pm UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/32 "2019-09-02T16:03:49Z")
> [@ardipa](#): > > Eric, how can we micro-dose BAQSIMI? Pour the powder out and cut it with an additive like laundry detergent or baking soda. You can cut it a little bit, but if you cut it too much your rep will drop and nobody will buy from you. Reputation is everything in that business. Just kidding! 🙂 * * * * * * Seriously, I don’t think there is a very practical way to do that. I am guessing you could take the powder out ahead of time and put it in a small container. And then snort just a little portion of it when needed instead of the whole thing. But doing that when low does not seem like it would be easy. I don’t think there is really much of a good option with Baqsimi. ---
**Author:** ![TiaG](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/tiag/32/594_2.png) [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Post date:** [September 2, 2019, 4:34pm UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/33 "2019-09-02T16:34:42Z")
I’m sure someone who has a free one kicking around could take one apart and see how it works, but I don’t know why someone would… ---
**Author:** ![TiaG](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/tiag/32/594_2.png) [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Post date:** [September 2, 2019, 4:50pm UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/34 "2019-09-02T16:50:27Z")
So apparently one benefit of Basqimi for emergencies is that it begins working significantly faster than the injected stuff. Not sure why. Another thing I noticed is that they did a test in children and it raised bg not that much after 45 minutes ,to about 180 mg/DL on average from 55 mg/DL. To me, that’s actually a totally fine level and a far cry from the 300+ that we were always warned was possible with giving even the half-dose of the injected glucagon (see Figure 1): [https://onlinelibrary.wiley.com/doi/full/10.1111/pedi.12668](https://onlinelibrary.wiley.com/doi/full/10.1111/pedi.12668) The cost and inability to microdose is for sure a huge issue of course for most diabetics. But it seems to me that, for emergency situations, it’s significantly better for kids in a school setting. ---
**Author:** ![ardipa](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/ardipa/32/3570_2.png) [@ardipa](https://forum.fudiabetes.org/u/ardipa)\ **Post date:** [September 2, 2019, 7:59pm UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/35 "2019-09-02T19:59:06Z")
Apparently another plus for baqsimi is it can be used for unconscious child or adult. No need to snort (inhale) it. ---
**Author:** ![T1Allison](https://avatars.discourse-cdn.com/v4/letter/t/c77e96/32.png) [@T1Allison](https://forum.fudiabetes.org/u/T1Allison)\ **Post date:** [September 3, 2019, 10:47am UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/36 "2019-09-03T10:47:05Z")
How’s Liam feeling now? ---
**Author:** ![ClaudnDaye](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/claudndaye/32/5_2.png) [@ClaudnDaye](https://forum.fudiabetes.org/u/ClaudnDaye)\ **Post date:** [September 3, 2019, 10:56am UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/37 "2019-09-03T10:56:29Z")
He’s feeling ok but his bgs are acting strangely. Since his stomach bug or whatever it was his insulin requirements seem to have gone down, so I’m battling lows and trying to figure out what’s the right new mix… Hopefully it’s right for the first day back to school today. I had to pick him up last Thursday at noon due to a persistant lows that wouldn’t come up. Nurse asked if I could get him since he was only in her office anyway. ---
**Author:** ![T1Allison](https://avatars.discourse-cdn.com/v4/letter/t/c77e96/32.png) [@T1Allison](https://forum.fudiabetes.org/u/T1Allison)\ **Post date:** [September 3, 2019, 11:34am UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/38 "2019-09-03T11:34:32Z")
I hope it gets back to normal soon! ---
**Author:** ![ClaudnDaye](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/claudndaye/32/5_2.png) [@ClaudnDaye](https://forum.fudiabetes.org/u/ClaudnDaye)\ **Post date:** [September 3, 2019, 11:48am UTC](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228/39 "2019-09-03T11:48:34Z")
Thanks so much for checking in on him! He’s definitely NOT 100% yet but hopefully this week he’ll get there. [Previous page](https://forum.fudiabetes.org/t/firsts-used-glucagon-tonight-09012019/8228.md?page=1)