# Effect of Glucagon - dependent on amount of liver glycogen available
**URL:** https://forum.fudiabetes.org/t/effect-of-glucagon-dependent-on-amount-of-liver-glycogen-available/1426
**Category:** Type 1 & LADA
**Tags:** glucagon
**Created:** [July 17, 2017, 6:52pm UTC](https://forum.fudiabetes.org/t/effect-of-glucagon-dependent-on-amount-of-liver-glycogen-available/1426 "2017-07-17T18:52:13Z")
**Posts on this page:** 2
**Page:** 1
### Author:  [@Eric](https://forum.fudiabetes.org/u/Eric)
#### Post date: [July 17, 2017, 6:52pm UTC](https://forum.fudiabetes.org/t/effect-of-glucagon-dependent-on-amount-of-liver-glycogen-available/1426/1 "2017-07-17T18:52:13Z")
In the [expired-glucagon](https://forum.fudiabetes.org/t/expired-glucagon/1417) thread, I experimented with some expired glucagon, doing a mini-dose. Then I tried it again the next day to see how it would work after the glucagon had been mixed for a day and left out.
The expired glucagon worked both first and second day, but what was interesting to me is the big difference I saw in how it affected my BG. Both times I used the same dose, a mini-dose of 25 units instead of the whole 100 units of solution.
**First day:**
51 to 109, **58** points in 32 minutes
**Second day:**
66 to 172, **106** points in 35 minutes.
Both situations were similar in terms of no IOB, time of day, starting BG, etc.
But there was a huge difference in how much of a BG rise I got out of the injection.
I realize the difference is because of the amount of available liver glycogen I had at the time.
On the first day, I did the dose about 16 hours after a fairly extreme glycogen depleting workout. I was pretty close to empty, and my body did not have enough time to fully replenish.
The second day was following a very easy workout, plus a big meal.
I think this was a good illustration of the difference between using glucagon when you are in a somewhat glycogen-depleted state, versus using it when your glycogen stores are more full.
Possibly useful information if you are doing fairly extensive exercise and you ever need a glucagon injection.
And one of the reasons I have been strongly advising people to restore those carbs **right away** after exercise. You never know when you might need them!
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### Author:  [@cardamom](https://forum.fudiabetes.org/u/cardamom)
#### Post date: [July 17, 2017, 11:04pm UTC](https://forum.fudiabetes.org/t/effect-of-glucagon-dependent-on-amount-of-liver-glycogen-available/1426/2 "2017-07-17T23:04:21Z")
It would be interesting to also look at with small amounts of alcohol in your system—I know alcohol suppresses glycogen release, but I wonder how dramatic the effects are and whether they are dose-dependent (i.e., will a very small amount in your system still completely suppress glycogen production until it’s gone, or will it only suppress it somewhat whereas more alcohol suppresses it more)?