# Are Basaglar and Lantus the same? **URL:** \ **Category:** wiki\ **Tags:** insulin, basal\ **Created:** [April 12, 2017, 8:31pm UTC](https://forum.fudiabetes.org/t/are-basaglar-and-lantus-the-same/452 "2017-04-12T20:31:41Z")\ **Posts on this page:** 4\ **Page:** 3
**Author:** ![Eric](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/eric/32/9209_2.png) [@Eric](https://forum.fudiabetes.org/u/Eric)\ **Post date:** [April 25, 2018, 7:36pm UTC](https://forum.fudiabetes.org/t/are-basaglar-and-lantus-the-same/452/41 "2018-04-25T19:36:41Z")
> [@lh378](#): > > I haven’t found an explanation for Levemir mechanism yet. Levemir binds to the albumin of the blood which prevents it from being rapidly used. In theory, you could inject Levemir directly into a vein and it would not be used all at once. Lantus was always predictable for me. I used it many years. But I think Levemir is more predictable. > [@lh378](#): > > The whole “time release” medication is a pretty tricky technology. I don’t really care for the “long acting” pain reliever, time release capsule. The encapsulation, the agglomeration, the dissolution rate…etc. that can all be so tricky to achieve. I’m old fashioned in that regard; just let me take my pain reliever every 4 to 6 hours as needed. I understand the concern. Have you ever used a pump? I think the slower basal release of things like Lantus, Levemir, or Tresiba are actually more predictable than the things that happen with a pump - which are subject to absorption and site issues, different sites, time since the pump infusion. All kinds of things. The drawback for me for Tresiba is the longer than 1 day duration, which makes ramping it down more difficult. At my dosing, Levemir is ideal since its duration is 12 hours. That let’s me do adjustments for different days, and also different amounts for night and day. 12 hours is a pretty good duration for a basal insulin for my needs. But if someone took a higher dose, then Levemir gets into the 16-18 hour range, or even up to 23 hours, and that might be less ideal. ---
**Author:** ![lh378](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/lh378/32/601_2.png) [@lh378](https://forum.fudiabetes.org/u/lh378)\ **Post date:** [April 26, 2018, 1:25pm UTC](https://forum.fudiabetes.org/t/are-basaglar-and-lantus-the-same/452/42 "2018-04-26T13:25:53Z")
That’s very interesting. I had a one month trial of the omnipod. The pod’s lowest dosage was too much for me. For some reason, more effective absorption, shorter needle…etc. led to a significantly lower TDD. My TDD on the omnipod was only about a fraction of my MDI. I had to repeatedly suspend my pod…so the long and short of it is that the omni pod pump did not work for me. In truth, I feel more “free” with MDI than on the omnipod. Before switching to Tresiba, I did use Levemir for awhile (after a few disastrous scary lows from Lantus). But at the time, I was not yet enlightened by this group of very well informed PWD. Therefore, if I were achieving less than optimal BG control, I cannot attribute it to Levemir. I would probably be willing to return to Levemir to try it out. I still have a small supply of Levemir. ---
**Author:** ![Eric](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/eric/32/9209_2.png) [@Eric](https://forum.fudiabetes.org/u/Eric)\ **Post date:** [April 26, 2018, 3:57pm UTC](https://forum.fudiabetes.org/t/are-basaglar-and-lantus-the-same/452/43 "2018-04-26T15:57:30Z")
> [@lh378](#): > > I would probably be willing to return to Levemir to try it out. I still have a small supply of Levemir. The trick with Levemir (which you may not have been told!) is to do it twice a day. That also allows you to vary your daytime and nighttime basal amounts which can be super helpful. Here is an excerpt on the mechanism of slowing Levemir: > The duration of action of LEVEMIR is mediated by slowed systemic absorption of insulin detemir molecules from the injection site due to self-association of the drug molecules. In addition, the distribution of insulin detemir to peripheral target tissues is slowed because of binding to albumin. And here is the info on the duration of Levemir. > **RESULTS:** > Duration of action for insulin detemir was dose dependent and varied from 5.7, to 12.1, to 19.9, to 22.7, to 23.2 h for 0.1, 0.2, 0.4, 0.8, and 1.6 units/kg, respectively. That sentence is horribly written and would make my 2nd grade teacher roll in her grave, but the idea is the amount in units per kg and duration are like this: - 0.1 units/kg lasts up to 5.7 hours - 0.2 units/kg lasts up to 12.1 hours - 0.4 units/kg lasts up to 19.9 hours - 0.8 units/kg lasts up to 22.7 hours - 1.6 units/kg lasts up to 23.2 hours Here is the link: > **[A double-blind, randomized, dose-response study investigating the...](https://pubmed.ncbi.nlm.nih.gov/15855574/)** > > This study shows that insulin detemir provides a flat and protracted pharmacodynamic profile. ---
**Author:** ![lh378](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.fudiabetes.org/lh378/32/601_2.png) [@lh378](https://forum.fudiabetes.org/u/lh378)\ **Post date:** [April 26, 2018, 4:28pm UTC](https://forum.fudiabetes.org/t/are-basaglar-and-lantus-the-same/452/44 "2018-04-26T16:28:32Z")
> [@Eric](#): > > That sentence is horribly written and would make my 2nd grade teacher roll in her grave, LOL- I was just invited to a “desert reception”…I certainly do not want to go to the desert for any type of reception. Shaking my head. [Previous page](https://forum.fudiabetes.org/t/are-basaglar-and-lantus-the-same/452.md?page=2)