# T1 Research **URL:** https://forum.fudiabetes.org/c/diabetes-type-1-lada/t1-research/62.md?page=4 [Latest](https://forum.fudiabetes.org/latest.md) · [Categories](https://forum.fudiabetes.org/categories.md) · [Tags](https://forum.fudiabetes.org/tags.md) **Page:** 5 --- ## [Tandem t:slim - PLGS trial enrollment started](https://forum.fudiabetes.org/t/tandem-t-slim-plgs-trial-enrollment-started/1592)
**Author:** [@Thomas](https://forum.fudiabetes.org/u/Thomas)\ **Replies:** 26\ **Last updated:** [November 16, 2017, 9:12pm UTC](https://forum.fudiabetes.org/t/tandem-t-slim-plgs-trial-enrollment-started/1592 "2017-11-16T21:12:33Z")
Awesome!!! Finally!!! Estimated Enrollment: 90 Anticipated Study Start Date: August 2017 Estimated Study Completion Date: November 2017 --- ## [Exercise really IS good for you!](https://forum.fudiabetes.org/t/exercise-really-is-good-for-you/2601)
**Author:** [@CatLady](https://forum.fudiabetes.org/u/CatLady)\ **Replies:** 19\ **Last updated:** [November 10, 2017, 5:39pm UTC](https://forum.fudiabetes.org/t/exercise-really-is-good-for-you/2601 "2017-11-10T17:39:52Z")
--- ## [Promising research?](https://forum.fudiabetes.org/t/promising-research/2563)
**Author:** [@CatLady](https://forum.fudiabetes.org/u/CatLady)\ **Replies:** 7\ **Last updated:** [November 6, 2017, 3:27pm UTC](https://forum.fudiabetes.org/t/promising-research/2563 "2017-11-06T15:27:58Z")
--- ## [Access to "Risk of kidney disease in T1DM" in Nature Reviews Endocrinology?](https://forum.fudiabetes.org/t/access-to-risk-of-kidney-disease-in-t1dm-in-nature-reviews-endocrinology/2282)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 1\ **Last updated:** [October 9, 2017, 12:24am UTC](https://forum.fudiabetes.org/t/access-to-risk-of-kidney-disease-in-t1dm-in-nature-reviews-endocrinology/2282 "2017-10-09T00:24:18Z")
If anyone has access to this paper, would they be able to submit a fair use review of the article here? it appears to be an interesting 50-year retrospective statistical analysis of kidney disease in T1Ds. https://www.n… --- ## [Insulinomas regenerate beta-cells](https://forum.fudiabetes.org/t/insulinomas-regenerate-beta-cells/2283)
**Author:** [@Cam\_TdT](https://forum.fudiabetes.org/u/Cam_TdT)\ **Replies:** 0\ **Last updated:** [October 6, 2017, 10:27pm UTC](https://forum.fudiabetes.org/t/insulinomas-regenerate-beta-cells/2283 "2017-10-06T22:27:52Z")
Insulinomas are (in general) benign tumors that are largely composed of regenerated beta cells, and that produce insulin. This study identified the genomic differences between regular beta cells and insulinomas: What… --- ## [Practical Cure from Stem Cells Arabia](https://forum.fudiabetes.org/t/practical-cure-from-stem-cells-arabia/2240)
**Author:** [@Bradford](https://forum.fudiabetes.org/u/Bradford)\ **Replies:** 4\ **Last updated:** [October 6, 2017, 1:57pm UTC](https://forum.fudiabetes.org/t/practical-cure-from-stem-cells-arabia/2240 "2017-10-06T13:57:06Z")
A new trial is underway with exciting preliminary results from a pilot study. 4 patients were treated with a combination of 2 stem cell procedures and went months without needing to inject insulin…all WITHOUT anti-rejec… --- ## [Study: genetics and Type 1 diabetes](https://forum.fudiabetes.org/t/study-genetics-and-type-1-diabetes/2251)
**Author:** [@MaryPat](https://forum.fudiabetes.org/u/MaryPat)\ **Replies:** 5\ **Last updated:** [October 4, 2017, 9:11pm UTC](https://forum.fudiabetes.org/t/study-genetics-and-type-1-diabetes/2251 "2017-10-04T21:11:06Z")
The Trialnet study, which many of us with T1 children are familiar with, has been generating some interesting data on genetics. Their most recent statistical analysis had some interesting conclusions: Type 1 and LADA a… --- ## [Neuropathy: possible research breakthourgh on HCN2 protein](https://forum.fudiabetes.org/t/neuropathy-possible-research-breakthourgh-on-hcn2-protein/2197)
**Author:** [@MaryPat](https://forum.fudiabetes.org/u/MaryPat)\ **Replies:** 5\ **Last updated:** [September 29, 2017, 2:24am UTC](https://forum.fudiabetes.org/t/neuropathy-possible-research-breakthourgh-on-hcn2-protein/2197 "2017-09-29T02:24:06Z")
According to this study, drugs that block HCN2 protein channels (it is an ion channel, that allows passage through the cell membrane) appear to completely stop neuropathic pain: “The researchers also found that blocki… --- ## [Artificial sweeteners](https://forum.fudiabetes.org/t/artificial-sweeteners/2132)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 16\ **Last updated:** [September 26, 2017, 7:41am UTC](https://forum.fudiabetes.org/t/artificial-sweeteners/2132 "2017-09-26T07:41:27Z")
Interesting, though of course preliminary given it’s in such a small group of people and we don’t understand much about the gut microbiome. http://www.medscape.com/viewarticle/885945 --- ## [Kidney disease is more common than not at 50 years T1D duration](https://forum.fudiabetes.org/t/kidney-disease-is-more-common-than-not-at-50-years-t1d-duration/2118)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 7\ **Last updated:** [September 23, 2017, 2:24am UTC](https://forum.fudiabetes.org/t/kidney-disease-is-more-common-than-not-at-50-years-t1d-duration/2118 "2017-09-23T02:24:37Z")
Well, there are a lot of questions here – namely that people who have 50 years of T1D under their belt likely spend decades in the “dark ages” of diabetes care no matter what their A1C now. But I’m inclined to suspect th… --- ## [Increase in prevalence of Type 1 diabetes: why?](https://forum.fudiabetes.org/t/increase-in-prevalence-of-type-1-diabetes-why/2064)
**Author:** [@Aaron](https://forum.fudiabetes.org/u/Aaron)\ **Replies:** 8\ **Last updated:** [September 19, 2017, 8:48pm UTC](https://forum.fudiabetes.org/t/increase-in-prevalence-of-type-1-diabetes-why/2064 "2017-09-19T20:48:11Z")
I have not done a study to prove a causal relationship, but I suspect that there would be a correlation between Type 1 diabetics living long enough to reproduce and pass on their genes and the increase of which you spea… --- ## [What is the average A1c of T1D patients: study](https://forum.fudiabetes.org/t/what-is-the-average-a1c-of-t1d-patients-study/1129)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 10\ **Last updated:** [September 14, 2017, 10:48pm UTC](https://forum.fudiabetes.org/t/what-is-the-average-a1c-of-t1d-patients-study/1129 "2017-09-14T22:48:52Z")
Here is what it looks like by age (as of 2015): \[image\] The poor performance of late teens and young adults is striking. In each age group, how many reach the recommended therapeutic goals (7.5% under age 19, 7% ab… --- ## [First ever cell-based gene therapy approved by FDA](https://forum.fudiabetes.org/t/first-ever-cell-based-gene-therapy-approved-by-fda/1798)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 2\ **Last updated:** [August 31, 2017, 3:14pm UTC](https://forum.fudiabetes.org/t/first-ever-cell-based-gene-therapy-approved-by-fda/1798 "2017-08-31T15:14:20Z")
This is pretty neat. This is not a pure diabetes news – but it has a strong impact. Yesterday, the FDA approved the first ever cell-based gene therapy treatment in the US, in this case for a form of juvenile leukemia (ac… --- ## [Study will try to create pancreatic islets from stem cells :-)](https://forum.fudiabetes.org/t/study-will-try-to-create-pancreatic-islets-from-stem-cells/1706)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 2\ **Last updated:** [August 24, 2017, 2:58pm UTC](https://forum.fudiabetes.org/t/study-will-try-to-create-pancreatic-islets-from-stem-cells/1706 "2017-08-24T14:58:12Z")
I think this direction of research is pretty exciting! These researchers at U Pittsburg are working on the ability to create pancreatic islets (also called islets of Langerhans, i.e. Beta cells) from stem cells: The r… --- ## [Thyroid antibodies and disease progression to hypothyroidism](https://forum.fudiabetes.org/t/thyroid-antibodies-and-disease-progression-to-hypothyroidism/1388)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 1\ **Last updated:** [July 10, 2017, 6:30pm UTC](https://forum.fudiabetes.org/t/thyroid-antibodies-and-disease-progression-to-hypothyroidism/1388 "2017-07-10T18:30:47Z")
So, a 70-year-old relative recently tested positive for thyroid antibodies. But his current tests show he has totally normal thyroid function. This is his first time being tested so we have no idea how long he's had thes… --- ## [Cord blood, cord tissue?](https://forum.fudiabetes.org/t/cord-blood-cord-tissue/1490)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 7\ **Last updated:** [July 29, 2017, 7:19pm UTC](https://forum.fudiabetes.org/t/cord-blood-cord-tissue/1490 "2017-07-29T19:19:21Z")
Wondering if folks here have done any research on the potential T1D treatments that may involve cord blood and/or cord tissue? With the upcoming baby we are probably going to do the cord blood banking. Even if the odds … --- ## ["Responders" May Delay onset of Type 1 Diabetes with Oral Insulin](https://forum.fudiabetes.org/t/responders-may-delay-onset-of-type-1-diabetes-with-oral-insulin/1316)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 1\ **Last updated:** [June 23, 2017, 9:39pm UTC](https://forum.fudiabetes.org/t/responders-may-delay-onset-of-type-1-diabetes-with-oral-insulin/1316 "2017-06-23T21:39:29Z")
I find this really fascinating because it really points to something I’ve suspected for a while; that it’s possible we may have already found a number of treatments that, in a small subset of people, can improve prognosi… --- ## [Half of T1Ds may produce insulin -- namely people who produce more of an antinflammatory compound](https://forum.fudiabetes.org/t/half-of-t1ds-may-produce-insulin-namely-people-who-produce-more-of-an-antinflammatory-compound/1317)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 0\ **Last updated:** [June 23, 2017, 6:41pm UTC](https://forum.fudiabetes.org/t/half-of-t1ds-may-produce-insulin-namely-people-who-produce-more-of-an-antinflammatory-compound/1317 "2017-06-23T18:41:49Z")
Wish there was some way of stimulating IL-35 to boost this anti-inflammatory effect. --- ## [How insulin diffuses from subcutaneous tissue](https://forum.fudiabetes.org/t/how-insulin-diffuses-from-subcutaneous-tissue/1295)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 4\ **Last updated:** [June 23, 2017, 3:25pm UTC](https://forum.fudiabetes.org/t/how-insulin-diffuses-from-subcutaneous-tissue/1295 "2017-06-23T15:25:13Z")
We are not hunks of dead meat obviously, but I thought this was a really cool visualization of how insulin travels through tissue to enter the bloodstream. One interesting tidbit: Heinemann1 estimated the coefficient of … --- ## [I'm writing a book that includes a child with diabetes. I would really appreciate any help I could get to better understand diabetes and maybe have some questions answered](https://forum.fudiabetes.org/t/im-writing-a-book-that-includes-a-child-with-diabetes-i-would-really-appreciate-any-help-i-could-get-to-better-understand-diabetes-and-maybe-have-some-questions-answered/1225)
**Author:** [@Skipper\_of\_Stones](https://forum.fudiabetes.org/u/Skipper_of_Stones)\ **Replies:** 32\ **Last updated:** [June 13, 2017, 2:47am UTC](https://forum.fudiabetes.org/t/im-writing-a-book-that-includes-a-child-with-diabetes-i-would-really-appreciate-any-help-i-could-get-to-better-understand-diabetes-and-maybe-have-some-questions-answered/1225 "2017-06-13T02:47:03Z")
Hello, This forum was recommended to me as a good source of information on diabetes. I'm writing a book that includes a four-year-old boy with diabetes. Most of the story that will include this child will be a surviv… --- ## [Beta Bionics artificial pancreas completed Phase 2A trials](https://forum.fudiabetes.org/t/beta-bionics-artificial-pancreas-completed-phase-2a-trials/1181)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 2\ **Last updated:** [June 7, 2017, 10:00pm UTC](https://forum.fudiabetes.org/t/beta-bionics-artificial-pancreas-completed-phase-2a-trials/1181 "2017-06-07T22:00:59Z")
It is the company that is working on the dual insulin-glucagon pump, mentioned in @TiaG's mini-glucagon thread. I can't see it on their site, though. Here is the announcement, which is totally bereft of details on the … --- ## [Engineered Micro Pancreas in mice](https://forum.fudiabetes.org/t/engineered-micro-pancreas-in-mice/1170)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 0\ **Last updated:** [June 7, 2017, 3:05am UTC](https://forum.fudiabetes.org/t/engineered-micro-pancreas-in-mice/1170 "2017-06-07T03:05:59Z")
This interesting company makes micro pancreas constructs on scaffolds made out of lung tissue. They just won a pharmaceutical prize in Israel: The thing I liked: no vascularization needed -- and you need a whole lot… --- ## [Do we all need a personalized glycemic index?](https://forum.fudiabetes.org/t/do-we-all-need-a-personalized-glycemic-index/1168)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 4\ **Last updated:** [June 7, 2017, 2:19am UTC](https://forum.fudiabetes.org/t/do-we-all-need-a-personalized-glycemic-index/1168 "2017-06-07T02:19:07Z")
I've been following this work and find it really fascinating. If this data is borne out, then what people reallyneed to do is keep a logbook of every individual food they eat and how it affects BG numbers. A bolus librar… --- ## [Challenge: can you find ANYTHING of value in this research paper?](https://forum.fudiabetes.org/t/challenge-can-you-find-anything-of-value-in-this-research-paper/1148)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 11\ **Last updated:** [June 5, 2017, 4:56pm UTC](https://forum.fudiabetes.org/t/challenge-can-you-find-anything-of-value-in-this-research-paper/1148 "2017-06-05T16:56:36Z")
I just read this article, with 16 authors (!!!), about the use of CGMs in studies: Role of Continuous Glucose Monitoring in Clinical Trials: Recommendations on Reporting I read paragraph after paragraph, hoping to gl… --- ## [The "Sugar Sponge"](https://forum.fudiabetes.org/t/the-sugar-sponge/1110)
**Author:** [@docslotnick](https://forum.fudiabetes.org/u/docslotnick)\ **Replies:** 1\ **Last updated:** [June 1, 2017, 3:03am UTC](https://forum.fudiabetes.org/t/the-sugar-sponge/1110 "2017-06-01T03:03:30Z")
An interesting concept in blood glucose control involves polymer chemistry: --- ## [Smart Insulin Made Using Red Blood Cells?](https://forum.fudiabetes.org/t/smart-insulin-made-using-red-blood-cells/1036)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 8\ **Last updated:** [May 30, 2017, 6:10pm UTC](https://forum.fudiabetes.org/t/smart-insulin-made-using-red-blood-cells/1036 "2017-05-30T18:10:26Z")
This seems like a pretty cool technique, though of course it's in mice. They essentially bound insulin molecules to a glucose-analog called glucosamine, and the whole ensemble acts like a smart insulin that operates when… --- ## [Is Type 1 diabetes linked to gut bacteria?](https://forum.fudiabetes.org/t/is-type-1-diabetes-linked-to-gut-bacteria/1044)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 2\ **Last updated:** [May 25, 2017, 1:58pm UTC](https://forum.fudiabetes.org/t/is-type-1-diabetes-linked-to-gut-bacteria/1044 "2017-05-25T13:58:44Z")
This interesting research from Joslin research center on mice shows strong links between the two. What I like most abt this research direction is that they are already jumping from mice to men: Diabetes researchers h… --- ## [Was getting excited, until the 8th paragraph](https://forum.fudiabetes.org/t/was-getting-excited-until-the-8th-paragraph/1020)
**Author:** [@Chris](https://forum.fudiabetes.org/u/Chris)\ **Replies:** 6\ **Last updated:** [May 24, 2017, 8:35pm UTC](https://forum.fudiabetes.org/t/was-getting-excited-until-the-8th-paragraph/1020 "2017-05-24T20:35:25Z")
--- ## [Bioengineering of an Intraabdominal Endocrine Pancreas](https://forum.fudiabetes.org/t/bioengineering-of-an-intraabdominal-endocrine-pancreas/896)
**Author:** [@docslotnick](https://forum.fudiabetes.org/u/docslotnick)\ **Replies:** 1\ **Last updated:** [May 12, 2017, 1:51am UTC](https://forum.fudiabetes.org/t/bioengineering-of-an-intraabdominal-endocrine-pancreas/896 "2017-05-12T01:51:05Z")
Report of a successful islet cell transplant into the omentum of a 43 year old woman with a 25 year history of T1 diabetes. Upside is obviously it worked without having to implant the islet cells into the liver. Downsid… --- ## [T1 mortality rates](https://forum.fudiabetes.org/t/t1-mortality-rates/224)
**Author:** [@britt\_j](https://forum.fudiabetes.org/u/britt_j)\ **Replies:** 24\ **Last updated:** [May 2, 2017, 10:54pm UTC](https://forum.fudiabetes.org/t/t1-mortality-rates/224 "2017-05-02T22:54:12Z")
I’m currently on my phablet, so it makes editing and providing citations a bit difficult. I’ll provide some counterpoints as time allows throughout the day. Let’s start w/ “Myth: As far as diseases go, Diabetes isn’t th… [Previous page](https://forum.fudiabetes.org/c/diabetes-type-1-lada/t1-research/62.md?page=3) [Next page](https://forum.fudiabetes.org/c/diabetes-type-1-lada/t1-research/62.md?page=5)