# T1 Research **URL:** https://forum.fudiabetes.org/c/diabetes-type-1-lada/t1-research/62.md?page=2 [Latest](https://forum.fudiabetes.org/latest.md) · [Categories](https://forum.fudiabetes.org/categories.md) · [Tags](https://forum.fudiabetes.org/tags.md) **Page:** 3 --- ## [Several studies in Science Magazine on T1D and Autoimmunity](https://forum.fudiabetes.org/t/several-studies-in-science-magazine-on-t1d-and-autoimmunity/7186)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 0\ **Last updated:** [April 9, 2019, 6:21pm UTC](https://forum.fudiabetes.org/t/several-studies-in-science-magazine-on-t1d-and-autoimmunity/7186 "2019-04-09T18:21:05Z")
Just starting to look at these but they seem interesting. Of course, involving mice, but still… https://immunology.sciencemag.org/ --- ## [No Benefit of Pumps Compared to MDI in Children: Study](https://forum.fudiabetes.org/t/no-benefit-of-pumps-compared-to-mdi-in-children-study/7150)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 15\ **Last updated:** [April 7, 2019, 7:52pm UTC](https://forum.fudiabetes.org/t/no-benefit-of-pumps-compared-to-mdi-in-children-study/7150 "2019-04-07T19:52:43Z")
An interesting read. Obviously, we’re on a pump, so we think it’s better for our family, but some of the numbers in this study are striking – namely the higher rate of adverse events on a pump: https://www.bmj.com/conten… --- ## [Azithromycin Starts A Phase-II? Clinical Trial (AIDIT)](https://forum.fudiabetes.org/t/azithromycin-starts-a-phase-ii-clinical-trial-aidit/7048)
**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\ **Replies:** 1\ **Last updated:** [March 24, 2019, 12:25am UTC](https://forum.fudiabetes.org/t/azithromycin-starts-a-phase-ii-clinical-trial-aidit/7048 "2019-03-24T00:25:05Z")
I just posted a new blog: --- ## [TrialNet no longer funding rescreening?](https://forum.fudiabetes.org/t/trialnet-no-longer-funding-rescreening/7027)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 6\ **Last updated:** [March 21, 2019, 4:36am UTC](https://forum.fudiabetes.org/t/trialnet-no-longer-funding-rescreening/7027 "2019-03-21T04:36:19Z")
I just read a Facebook post saying that TrialNet is no longer offering yearly rescreening for autoantibody negative siblings. Apparently they lost their NIH funding. Does anyone know why and what’s going on? --- ## [Fascinating new approach to diabetes cure: stopping cell senescence](https://forum.fudiabetes.org/t/fascinating-new-approach-to-diabetes-cure-stopping-cell-senescence/6783)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 12\ **Last updated:** [March 8, 2019, 9:03pm UTC](https://forum.fudiabetes.org/t/fascinating-new-approach-to-diabetes-cure-stopping-cell-senescence/6783 "2019-03-08T21:03:23Z")
This direction was fascinating to me because it is the first time I see it applied to diabetes—I also see some great potential! This brand new study, also out of UCSF (the third in a week!), looks at a radically differe… --- ## [New technique could remove need for immunosuppressants in Beta cell grafts](https://forum.fudiabetes.org/t/new-technique-could-remove-need-for-immunosuppressants-in-beta-cell-grafts/6707)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 12\ **Last updated:** [March 8, 2019, 9:01pm UTC](https://forum.fudiabetes.org/t/new-technique-could-remove-need-for-immunosuppressants-in-beta-cell-grafts/6707 "2019-03-08T21:01:55Z")
Warning: this technique has only been tried with mice so far :slight\_smile: Scientists at the University of California San Francisco have developed a new method to minimize the likelihood that a person’s body will re… --- ## [T1 Diabetes risk linked to immune response to gut biome](https://forum.fudiabetes.org/t/t1-diabetes-risk-linked-to-immune-response-to-gut-biome/6723)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 9\ **Last updated:** [February 21, 2019, 5:24pm UTC](https://forum.fudiabetes.org/t/t1-diabetes-risk-linked-to-immune-response-to-gut-biome/6723 "2019-02-21T17:24:33Z")
This fascinating study links the risk to develop T1 diabetes to the strength of the immune system response to gut microbiota: Type 1 diabetes is \[…\] disease in which the immune system destroys the beta cells of the p… --- ## [These marine snails kill with super-fast insulin!](https://forum.fudiabetes.org/t/these-marine-snails-kill-with-super-fast-insulin/6563)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 5\ **Last updated:** [February 13, 2019, 1:53pm UTC](https://forum.fudiabetes.org/t/these-marine-snails-kill-with-super-fast-insulin/6563 "2019-02-13T13:53:06Z")
They poison their victims with insulin that induces quasi-immediate diabetic coma: --- ## [The WORST Headline](https://forum.fudiabetes.org/t/the-worst-headline/6472)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 8\ **Last updated:** [February 14, 2019, 8:17pm UTC](https://forum.fudiabetes.org/t/the-worst-headline/6472 "2019-02-14T20:17:43Z")
This makes me so annoyed: --- ## [Geographic variation in T1 incidence: why?](https://forum.fudiabetes.org/t/geographic-variation-in-t1-incidence-why/6558)
**Author:** [@Beacher](https://forum.fudiabetes.org/u/Beacher)\ **Replies:** 32\ **Last updated:** [February 14, 2019, 9:53am UTC](https://forum.fudiabetes.org/t/geographic-variation-in-t1-incidence-why/6558 "2019-02-14T09:53:00Z")
Welcome, @kalle. I didn’t know that statistic! I have had diabetes for nearly 50 years and have lived in England, Canada, and a year in Italy, and except for going to diabetic summer camp as a kid a few times, I have ne… --- ## [A better T1D mouse to test cure therapies](https://forum.fudiabetes.org/t/a-better-t1d-mouse-to-test-cure-therapies/6594)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 0\ **Last updated:** [February 14, 2019, 10:57am UTC](https://forum.fudiabetes.org/t/a-better-t1d-mouse-to-test-cure-therapies/6594 "2019-02-14T10:57:57Z")
University of Toledo’s Center for Medicine and Life Sciences has developed and patented a “better” T1 mouse, whose acquisition of the disease, and complications appear to map the human process well: Some excerpts: I… --- ## [Oral insulin feasibility trial research was just published](https://forum.fudiabetes.org/t/oral-insulin-feasibility-trial-research-was-just-published/6266)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 1\ **Last updated:** [February 12, 2019, 6:23pm UTC](https://forum.fudiabetes.org/t/oral-insulin-feasibility-trial-research-was-just-published/6266 "2019-02-12T18:23:08Z")
These are promising results: It’s really too bad that Novo discontinued this research: From the article: Findings from the phase 2 trial of Novo Nordisk’s investigational — and now discontinued — long-acting oral bas… --- ## [Recent research: do night snacks decrease hypoglycemia? Does protein help?](https://forum.fudiabetes.org/t/recent-research-do-night-snacks-decrease-hypoglycemia-does-protein-help/6519)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 34\ **Last updated:** [February 11, 2019, 6:57pm UTC](https://forum.fudiabetes.org/t/recent-research-do-night-snacks-decrease-hypoglycemia-does-protein-help/6519 "2019-02-11T18:57:21Z")
Conventional wisdom, as dispensed by most endos today, appears to say that bedtime snacks help in preventing nighttime hypoglycemia, and that snacks including protein are better because the effect lasts longer. But @MM2 … --- ## [How to find a clinical Trial (2019 Update)](https://forum.fudiabetes.org/t/how-to-find-a-clinical-trial-2019-update/6461)
**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\ **Replies:** 1\ **Last updated:** [February 6, 2019, 5:16pm UTC](https://forum.fudiabetes.org/t/how-to-find-a-clinical-trial-2019-update/6461 "2019-02-06T17:16:09Z")
New blog posting: --- ## [Recent research & question about conducting research through this site](https://forum.fudiabetes.org/t/recent-research-question-about-conducting-research-through-this-site/6339)
**Author:** [@bwschulz](https://forum.fudiabetes.org/u/bwschulz)\ **Replies:** 10\ **Last updated:** [January 31, 2019, 2:52am UTC](https://forum.fudiabetes.org/t/recent-research-question-about-conducting-research-through-this-site/6339 "2019-01-31T02:52:43Z")
I ran across these publications today and thought I’d share. Recent publication with positive results for the iAPS: https://www.liebertpub.com/doi/10.1089/dia.2018.0278 Data on diabetes management and outcomes from two… --- ## [Three Months Of New Studies](https://forum.fudiabetes.org/t/three-months-of-new-studies/6291)
**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\ **Replies:** 7\ **Last updated:** [January 30, 2019, 3:41am UTC](https://forum.fudiabetes.org/t/three-months-of-new-studies/6291 "2019-01-30T03:41:11Z")
I’ve just posted a new blog, which is a little different than my usual blogs. I went through all type-1 diabetes clinical trials which started in the last three months, and counted what they were focused on and which on… --- ## [Erythrocyte decoration as a path to immune tolerogenesis](https://forum.fudiabetes.org/t/erythrocyte-decoration-as-a-path-to-immune-tolerogenesis/6182)
**Author:** [@DoubleBee](https://forum.fudiabetes.org/u/DoubleBee)\ **Replies:** 6\ **Last updated:** [January 23, 2019, 12:04pm UTC](https://forum.fudiabetes.org/t/erythrocyte-decoration-as-a-path-to-immune-tolerogenesis/6182 "2019-01-23T12:04:05Z")
Hi All, I am relatively new T1 Dad and I have been using my work experience in biotech startups as a method for helping to see the light at the end of the tunnel. I am writing this here as a good part of my own persona… --- ## [Beta cell proliferation in adults](https://forum.fudiabetes.org/t/beta-cell-proliferation-in-adults/5816)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 4\ **Last updated:** [January 20, 2019, 2:34pm UTC](https://forum.fudiabetes.org/t/beta-cell-proliferation-in-adults/5816 "2019-01-20T14:34:26Z")
I thought this was an interesting study. Of course, they took their recipe book from insulinomas, which are basically benign forms of cancer. And you don’t want a bunch of off-target effects, and this isn’t even a mouse … --- ## [Diabetes Research: What's New Q1 2019 - Diabetes Self-Management](https://forum.fudiabetes.org/t/diabetes-research-whats-new-q1-2019-diabetes-self-management/6133)
**Author:** [@T1john](https://forum.fudiabetes.org/u/T1john)\ **Replies:** 0\ **Last updated:** [January 16, 2019, 8:42pm UTC](https://forum.fudiabetes.org/t/diabetes-research-whats-new-q1-2019-diabetes-self-management/6133 "2019-01-16T20:42:00Z")
Here’s the whole story --- ## [Ustekinumab Starts A Phase II Clinical Trial Called USTEKID](https://forum.fudiabetes.org/t/ustekinumab-starts-a-phase-ii-clinical-trial-called-ustekid/6117)
**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\ **Replies:** 1\ **Last updated:** [January 15, 2019, 10:49am UTC](https://forum.fudiabetes.org/t/ustekinumab-starts-a-phase-ii-clinical-trial-called-ustekid/6117 "2019-01-15T10:49:44Z")
Ustekinumab is starting a clinical trial in the UK: --- ## [The Risks of Hypoglycemia](https://forum.fudiabetes.org/t/the-risks-of-hypoglycemia/5221)
**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\ **Replies:** 20\ **Last updated:** [December 31, 2018, 2:21am UTC](https://forum.fudiabetes.org/t/the-risks-of-hypoglycemia/5221 "2018-12-31T02:21:10Z")
Given how long the glycemic variability thread has become, and given that we’re sort of skirting around a topic that keeps coming up, I thought it would be good to create a new thread on the risks of hypoglycemia. I’m go… --- ## [Hydroxychloroquine (Plaquenil) Starts a Phase-II? Trial To Prevent Type-1 In Presymptomatics](https://forum.fudiabetes.org/t/hydroxychloroquine-plaquenil-starts-a-phase-ii-trial-to-prevent-type-1-in-presymptomatics/5921)
**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\ **Replies:** 0\ **Last updated:** [December 24, 2018, 6:46am UTC](https://forum.fudiabetes.org/t/hydroxychloroquine-plaquenil-starts-a-phase-ii-trial-to-prevent-type-1-in-presymptomatics/5921 "2018-12-24T06:46:25Z")
I just posted a blog on a new clinical trial: --- ## [Blog on Vitamin D and Omega-3s (EPA/DHA "Fish Oil") Start a Patient Driven Study](https://forum.fudiabetes.org/t/blog-on-vitamin-d-and-omega-3s-epa-dha-fish-oil-start-a-patient-driven-study/5680)
**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\ **Replies:** 1\ **Last updated:** [December 1, 2018, 10:27pm UTC](https://forum.fudiabetes.org/t/blog-on-vitamin-d-and-omega-3s-epa-dha-fish-oil-start-a-patient-driven-study/5680 "2018-12-01T22:27:45Z")
I’ve just posted a long blog on a Vitamin D / Omega-3 study: Joshua --- ## [PWDs on SGLT2 inhibitors have 2x risk of amputation and DKA](https://forum.fudiabetes.org/t/pwds-on-sglt2-inhibitors-have-2x-risk-of-amputation-and-dka/5526)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 0\ **Last updated:** [November 17, 2018, 11:42am UTC](https://forum.fudiabetes.org/t/pwds-on-sglt2-inhibitors-have-2x-risk-of-amputation-and-dka/5526 "2018-11-17T11:42:08Z")
This is a new, large observational study, which muddies up the field of SGLT2 inhibitors. It links use of SGLT2 inhibitors in general with a 2x risk of lower limb amputation and of Diabetic Keto Acidosis. So far, one SG… --- ## [Diabecell Research Closes Out (With Comments on Encapsulation In General)](https://forum.fudiabetes.org/t/diabecell-research-closes-out-with-comments-on-encapsulation-in-general/3299)
**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\ **Replies:** 19\ **Last updated:** [November 14, 2018, 1:27am UTC](https://forum.fudiabetes.org/t/diabecell-research-closes-out-with-comments-on-encapsulation-in-general/3299 "2018-11-14T01:27:48Z")
Diabecell is an encapsulated pig beta cell treatment aimed at curing type-1 diabetes. This research started in the 1990s, and was part of a group of encapsulated stem cell cures which were developed at the same time by … --- ## [Bad news: cannabis associated with 80% higher risk of DKA!](https://forum.fudiabetes.org/t/bad-news-cannabis-associated-with-80-higher-risk-of-dka/5441)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 6\ **Last updated:** [November 11, 2018, 5:56am UTC](https://forum.fudiabetes.org/t/bad-news-cannabis-associated-with-80-higher-risk-of-dka/5441 "2018-11-11T05:56:09Z")
This JAMA letter discusses the association between self-reported cannabis use and DKA (diabetic ketoacidosis): To read the full article, you need to sign up for a free account—or you can read the summary on WebMD: T… --- ## [Golimumab Update](https://forum.fudiabetes.org/t/golimumab-update/5329)
**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\ **Replies:** 4\ **Last updated:** [November 1, 2018, 9:52am UTC](https://forum.fudiabetes.org/t/golimumab-update/5329 "2018-11-01T09:52:07Z")
I just posted a blog which is a general update to research on Golimumab (sold as Simponi). There are three clinical trials underway right now: --- ## [Study: this enzyme lowers BG without insulin](https://forum.fudiabetes.org/t/study-this-enzyme-lowers-bg-without-insulin/5204)
**Author:** [@Michel](https://forum.fudiabetes.org/u/Michel)\ **Replies:** 9\ **Last updated:** [October 17, 2018, 12:05am UTC](https://forum.fudiabetes.org/t/study-this-enzyme-lowers-bg-without-insulin/5204 "2018-10-17T00:05:26Z")
This interesting study discovered an enzyme that temporarily lowers BG without requiring insulin: Medical News Today: Could this amino acid improve glucose control in diabetes?. It appears that the amino acid \[alanin… --- ## [JDRF Funding for a Cure 2018](https://forum.fudiabetes.org/t/jdrf-funding-for-a-cure-2018/5156)
**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\ **Replies:** 5\ **Last updated:** [October 9, 2018, 5:13am UTC](https://forum.fudiabetes.org/t/jdrf-funding-for-a-cure-2018/5156 "2018-10-09T05:13:52Z")
I just made my annual blog posting which lists all clinical trials aimed at curing type-1 diabetes, and then describes which are funded by JDRF and which are not. It is a good posting both to see an overview of everythi… --- ## [Dropping Four Research Programs](https://forum.fudiabetes.org/t/dropping-four-research-programs/5105)
**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\ **Replies:** 6\ **Last updated:** [October 5, 2018, 5:18am UTC](https://forum.fudiabetes.org/t/dropping-four-research-programs/5105 "2018-10-05T05:18:28Z")
I just posted a blog on four research programs that I no longer think are cure focused research, either because they have not published any forward progress for a long time, or changed their focus away from a cure: I… [Previous page](https://forum.fudiabetes.org/c/diabetes-type-1-lada/t1-research/62.md?page=1) [Next page](https://forum.fudiabetes.org/c/diabetes-type-1-lada/t1-research/62.md?page=3)