# T1 Research

**URL:** https://forum.fudiabetes.org/c/diabetes-type-1-lada/t1-research/62.md?page=1

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## [Interesting research on med for T1s](https://forum.fudiabetes.org/t/interesting-research-on-med-for-t1s/10091)

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**Author:** [@CatLady](https://forum.fudiabetes.org/u/CatLady)\
**Replies:** 3\
**Last updated:** [August 4, 2020, 7:43pm UTC](https://forum.fudiabetes.org/t/interesting-research-on-med-for-t1s/10091 "2020-08-04T19:43:46Z")

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## [Inverse vaccine research for T1D](https://forum.fudiabetes.org/t/inverse-vaccine-research-for-t1d/9993)

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**Author:** [@Boerenkool](https://forum.fudiabetes.org/u/Boerenkool)\
**Replies:** 3\
**Last updated:** [July 17, 2020, 7:18am UTC](https://forum.fudiabetes.org/t/inverse-vaccine-research-for-t1d/9993 "2020-07-17T07:18:52Z")

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For those interested, results from a Phase 1 trial involving a vaccine to induce immune tolerance have been published: Original research article (Open Access): https://www.thelancet.com/journals/landia/article/PIIS…

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## [Once weekly long-acting insulin?](https://forum.fudiabetes.org/t/once-weekly-long-acting-insulin/9883)

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**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\
**Replies:** 31\
**Last updated:** [July 11, 2020, 3:14pm UTC](https://forum.fudiabetes.org/t/once-weekly-long-acting-insulin/9883 "2020-07-11T15:14:59Z")

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Novo Nordisk just completed a Phase II of this new insulin. Seems like a cool option if it passes Phase III trials. I can imagine this giving a little peace of mind to parents of forgetful teenagers, for instance…

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## [First data on T1D and COVID-19](https://forum.fudiabetes.org/t/first-data-on-t1d-and-covid-19/9784)

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**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\
**Replies:** 33\
**Last updated:** [June 8, 2020, 8:15pm UTC](https://forum.fudiabetes.org/t/first-data-on-t1d-and-covid-19/9784 "2020-06-08T20:15:13Z")

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Seems like death rates are 3X that of non-diabetics. Some mitigation by HbA1C, but not a ton: For younger people, death rates still seem low of course, but not as low as they would be if you don’t have T1D :frowning: …

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## [Interesting case study on remission in T1D with a cholesterol drug](https://forum.fudiabetes.org/t/interesting-case-study-on-remission-in-t1d-with-a-cholesterol-drug/9782)

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**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\
**Replies:** 2\
**Last updated:** [May 20, 2020, 4:47pm UTC](https://forum.fudiabetes.org/t/interesting-case-study-on-remission-in-t1d-with-a-cholesterol-drug/9782 "2020-05-20T16:47:00Z")

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It’s the definition of anecdata, but still interesting. My personal theory is that there may be dozens of things out there that could potentially put T1D into remission in one or two people in the world, but not on a mas…

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## [Results From a Phase-I Clinical Trial of IMCY-0098](https://forum.fudiabetes.org/t/results-from-a-phase-i-clinical-trial-of-imcy-0098/9424)

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**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\
**Replies:** 3\
**Last updated:** [April 4, 2020, 6:35pm UTC](https://forum.fudiabetes.org/t/results-from-a-phase-i-clinical-trial-of-imcy-0098/9424 "2020-04-04T18:35:07Z")

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After a long break, I just posted another blog: Unfortunately, the news is not good, but that’s the thing about research. Some will succeed some will not, and we just need one to succeed…

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## [A couple of small research updates in my blog](https://forum.fudiabetes.org/t/a-couple-of-small-research-updates-in-my-blog/9604)

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**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\
**Replies:** 0\
**Last updated:** [April 4, 2020, 4:46pm UTC](https://forum.fudiabetes.org/t/a-couple-of-small-research-updates-in-my-blog/9604 "2020-04-04T16:46:01Z")

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## [Dexcom g5 sensor expiration dates](https://forum.fudiabetes.org/t/dexcom-g5-sensor-expiration-dates/9377)

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**Author:** [@cmason3983](https://forum.fudiabetes.org/u/cmason3983)\
**Replies:** 3\
**Last updated:** [March 2, 2020, 6:26pm UTC](https://forum.fudiabetes.org/t/dexcom-g5-sensor-expiration-dates/9377 "2020-03-02T18:26:55Z")

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Hi my name is Chris I’m a type 1 l a d a i have no insurance and I found some expired sensors for sale dexcom G5 from 2016 and 2017 wondering people’s input if I should try them or not… PS if anyone has any G5 sensors t…

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## [Research on T1D prescreening in young children](https://forum.fudiabetes.org/t/research-on-t1d-prescreening-in-young-children/9312)

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**Author:** [@CatLady](https://forum.fudiabetes.org/u/CatLady)\
**Replies:** 3\
**Last updated:** [February 13, 2020, 7:07pm UTC](https://forum.fudiabetes.org/t/research-on-t1d-prescreening-in-young-children/9312 "2020-02-13T19:07:24Z")

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https://www.healthline.com/diabetesmine/screening-for-type-1-diabetes#Why-is-this-important?

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## [Blog posting on clinical trials using probiotics](https://forum.fudiabetes.org/t/blog-posting-on-clinical-trials-using-probiotics/8953)

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**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\
**Replies:** 0\
**Last updated:** [December 23, 2019, 7:12am UTC](https://forum.fudiabetes.org/t/blog-posting-on-clinical-trials-using-probiotics/8953 "2019-12-23T07:12:38Z")

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I wrote a blog posting on clinical trials using probiotics. It summarizes five studies which are currently underway:

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## [Avotres's AVT001 Starts A Phase-I Trial](https://forum.fudiabetes.org/t/avotress-avt001-starts-a-phase-i-trial/8803)

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**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\
**Replies:** 1\
**Last updated:** [December 4, 2019, 7:40am UTC](https://forum.fudiabetes.org/t/avotress-avt001-starts-a-phase-i-trial/8803 "2019-12-04T07:40:41Z")

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I’ve written a blog on a new cellular treatment for type-1 diabetes:

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## [Webinar on Time-in-Range on Thursday, 12/12/19 @11AM](https://forum.fudiabetes.org/t/webinar-on-time-in-range-on-thursday-12-12-19-11am/8802)

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**Author:** [@bwschulz](https://forum.fudiabetes.org/u/bwschulz)\
**Replies:** 0\
**Last updated:** [December 3, 2019, 4:06pm UTC](https://forum.fudiabetes.org/t/webinar-on-time-in-range-on-thursday-12-12-19-11am/8802 "2019-12-03T16:06:22Z")

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I received this invite at work but can’t attend at the scheduled time. It may be a bit data-science heavy, but feel free to register and attend if you want. It’s free as far as I can tell- they’ll just have your email ad…

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## [New Blog on Combo of AG019 and Teplizumab](https://forum.fudiabetes.org/t/new-blog-on-combo-of-ag019-and-teplizumab/8738)

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**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\
**Replies:** 0\
**Last updated:** [November 23, 2019, 4:07pm UTC](https://forum.fudiabetes.org/t/new-blog-on-combo-of-ag019-and-teplizumab/8738 "2019-11-23T16:07:40Z")

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Blog posting on a clinical trial which has been going on for a while, but which I have not blogged about before: AG019 is a pill containing an engineered micro-organism (Lactococcus lactis, often shortened to “L. lact…

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## [Is there any association between gut microbiota and type 1 diabetes?](https://forum.fudiabetes.org/t/is-there-any-association-between-gut-microbiota-and-type-1-diabetes/8685)

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**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\
**Replies:** 0\
**Last updated:** [November 16, 2019, 4:27am UTC](https://forum.fudiabetes.org/t/is-there-any-association-between-gut-microbiota-and-type-1-diabetes/8685 "2019-11-16T04:27:02Z")

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Published a new blog on a meta-analysis of gut microbiota: https://cureresearch4type1diabetes.blogspot.com/2019/11/is-there-any-association-between-gut.html

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## [Blog Overview of Research Aimed At A Cure In Human Trials](https://forum.fudiabetes.org/t/blog-overview-of-research-aimed-at-a-cure-in-human-trials/8488)

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**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\
**Replies:** 4\
**Last updated:** [October 20, 2019, 8:10pm UTC](https://forum.fudiabetes.org/t/blog-overview-of-research-aimed-at-a-cure-in-human-trials/8488 "2019-10-20T20:10:17Z")

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I’ve just posted a new blog article which is my yearly summary of all clinical trials aimed at curing/preventing/delaying T1D. This year there are 56 different trials going on, including 12 being run on people with long…

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## [TOL-3021 Starts A Phase-II Clinical Trial](https://forum.fudiabetes.org/t/tol-3021-starts-a-phase-ii-clinical-trial/8526)

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**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\
**Replies:** 0\
**Last updated:** [October 19, 2019, 8:24pm UTC](https://forum.fudiabetes.org/t/tol-3021-starts-a-phase-ii-clinical-trial/8526 "2019-10-19T20:24:08Z")

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I just wrote a new blog, which you can read here: This is the second human trial for TOL-3021.

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## [Recent NEJM publication on closed-loop CGM/pump system - probably getting near FDA approval now](https://forum.fudiabetes.org/t/recent-nejm-publication-on-closed-loop-cgm-pump-system-probably-getting-near-fda-approval-now/8514)

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**Author:** [@bwschulz](https://forum.fudiabetes.org/u/bwschulz)\
**Replies:** 0\
**Last updated:** [October 17, 2019, 3:18pm UTC](https://forum.fudiabetes.org/t/recent-nejm-publication-on-closed-loop-cgm-pump-system-probably-getting-near-fda-approval-now/8514 "2019-10-17T15:18:01Z")

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Dexcom/Tandem Control-IQ system (sensor-augmented pump and CGM combination) multi-site RCT comparing automatic vs. manual insulin delivery found 2.6 hours per day more (or 10% more) time in range and fewer highs and lows…

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## [30% reduction in T1D in kids under 4 years old when vaccinated for rotovirus](https://forum.fudiabetes.org/t/30-reduction-in-t1d-in-kids-under-4-years-old-when-vaccinated-for-rotovirus/8457)

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**Author:** [@bwschulz](https://forum.fudiabetes.org/u/bwschulz)\
**Replies:** 7\
**Last updated:** [October 13, 2019, 3:59am UTC](https://forum.fudiabetes.org/t/30-reduction-in-t1d-in-kids-under-4-years-old-when-vaccinated-for-rotovirus/8457 "2019-10-13T03:59:07Z")

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I ran across this article here- https://sciencebasedmedicine.org/vaccines-in-the-news-the-good-the-bad-and-the-imminent-loss-of-our-measles-elimination-status/ This was part of the “good”, but unfortunately it only work…

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## [Possible Cures for Type-1 in the News (September)](https://forum.fudiabetes.org/t/possible-cures-for-type-1-in-the-news-september/8416)

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**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\
**Replies:** 3\
**Last updated:** [September 30, 2019, 12:54am UTC](https://forum.fudiabetes.org/t/possible-cures-for-type-1-in-the-news-september/8416 "2019-09-30T00:54:26Z")

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I just published a blog covering three smaller research items:

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## [Teplizumab Phase-II Results For Prevention And Starts A Phase-III On Honeymooners](https://forum.fudiabetes.org/t/teplizumab-phase-ii-results-for-prevention-and-starts-a-phase-iii-on-honeymooners/8360)

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**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\
**Replies:** 1\
**Last updated:** [September 26, 2019, 9:43pm UTC](https://forum.fudiabetes.org/t/teplizumab-phase-ii-results-for-prevention-and-starts-a-phase-iii-on-honeymooners/8360 "2019-09-26T21:43:17Z")

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I just finished a new blog posting; my first in a while. It is long and complex but also important (I think). It covers one clinical trial run on people in TrialNet. People who had two autoantibodies but had not been dia…

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## [Gluten consumption during infancy tied to type 1 diabetes risk](https://forum.fudiabetes.org/t/gluten-consumption-during-infancy-tied-to-type-1-diabetes-risk/8404)

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**Author:** [@Boerenkool](https://forum.fudiabetes.org/u/Boerenkool)\
**Replies:** 0\
**Last updated:** [September 26, 2019, 9:14pm UTC](https://forum.fudiabetes.org/t/gluten-consumption-during-infancy-tied-to-type-1-diabetes-risk/8404 "2019-09-26T21:14:12Z")

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Researchers found that gluten intake at 18 months of age is associated with development of T1D. Interestingly, in a study published in May this year, the same researchers did not find an association between gluten int…

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## [\[real-time\] CGM, Not Insulin Pump, 'Is What Makes Difference' in Type 1 Diabetes](https://forum.fudiabetes.org/t/real-time-cgm-not-insulin-pump-is-what-makes-difference-in-type-1-diabetes/8355)

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**Author:** [@bwschulz](https://forum.fudiabetes.org/u/bwschulz)\
**Replies:** 15\
**Last updated:** [September 22, 2019, 11:00pm UTC](https://forum.fudiabetes.org/t/real-time-cgm-not-insulin-pump-is-what-makes-difference-in-type-1-diabetes/8355 "2019-09-22T23:00:14Z")

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As a longtime Dexcom user who has believed this ever since my first SevenGo took my A1C from 7.3 down to 5.7 it’s nice to see research published to support my personal experience. The headline of the article sums it up …

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## [Metformin reduces heart disease risk in Type 1s:](https://forum.fudiabetes.org/t/metformin-reduces-heart-disease-risk-in-type-1s/5290)

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**Author:** [@TiaG](https://forum.fudiabetes.org/u/TiaG)\
**Replies:** 18\
**Last updated:** [July 8, 2019, 4:24pm UTC](https://forum.fudiabetes.org/t/metformin-reduces-heart-disease-risk-in-type-1s/5290 "2019-07-08T16:24:01Z")

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It apparently improves heart disease markers and NOT because it’s lowering BGs; it has a completely different mechanism involving microRNAs that suppress new blood vessel growth: I love studies like these which show …

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## [Non Hormonal Insulin Regulation](https://forum.fudiabetes.org/t/non-hormonal-insulin-regulation/7730)

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**Author:** [@docslotnick](https://forum.fudiabetes.org/u/docslotnick)\
**Replies:** 1\
**Last updated:** [June 20, 2019, 7:13pm UTC](https://forum.fudiabetes.org/t/non-hormonal-insulin-regulation/7730 "2019-06-20T19:13:22Z")

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Researchers in Canada have developed a non-hormonal, insulin-free treatment for hyperglycemia using a glucose-responsive nanogel. It can be injected to keep blood sugar levels within a healthy range, and could treat diab…

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## [MER3101 Starts a Phase-I Clinical Trial](https://forum.fudiabetes.org/t/mer3101-starts-a-phase-i-clinical-trial/7728)

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**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\
**Replies:** 0\
**Last updated:** [June 19, 2019, 4:29am UTC](https://forum.fudiabetes.org/t/mer3101-starts-a-phase-i-clinical-trial/7728 "2019-06-19T04:29:53Z")

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I’ve written a blog on the start of a new clinical trial: Joshua

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## [New blog. Unfortunately it is two pieces of bad news](https://forum.fudiabetes.org/t/new-blog-unfortunately-it-is-two-pieces-of-bad-news/7369)

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**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\
**Replies:** 1\
**Last updated:** [May 2, 2019, 4:54am UTC](https://forum.fudiabetes.org/t/new-blog-unfortunately-it-is-two-pieces-of-bad-news/7369 "2019-05-02T04:54:14Z")

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Wrote a new blog. Unfortunately it is two pieces of bad news:

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## [Survey - Research](https://forum.fudiabetes.org/t/survey-research/7286)

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**Author:** [@MaryEliz](https://forum.fudiabetes.org/u/MaryEliz)\
**Replies:** 5\
**Last updated:** [April 22, 2019, 6:38pm UTC](https://forum.fudiabetes.org/t/survey-research/7286 "2019-04-22T18:38:55Z")

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Hey there! One Drop is giving away three chances to win a $100 Amazon gift card. Click below to take a 5-minute survey on how you manage diabetes: THANK YOU!!! Mary Elizabeth

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## [What statistics on insulin use are available?](https://forum.fudiabetes.org/t/what-statistics-on-insulin-use-are-available/7258)

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**Author:** [@Boerenkool](https://forum.fudiabetes.org/u/Boerenkool)\
**Replies:** 5\
**Last updated:** [April 20, 2019, 6:50pm UTC](https://forum.fudiabetes.org/t/what-statistics-on-insulin-use-are-available/7258 "2019-04-20T18:50:38Z")

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I found these statistics from Tidepool and noticed that in a couple of these plots I’m at the extremes of the distribution. Of course there’s nothing wrong with that, but I’m curious what could explain the differences. D…

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## [Can A Rotavirus Vaccine Prevent Type 1 Diabetes In Some People?](https://forum.fudiabetes.org/t/can-a-rotavirus-vaccine-prevent-type-1-diabetes-in-some-people/7255)

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**Author:** [@joshualevy](https://forum.fudiabetes.org/u/joshualevy)\
**Replies:** 0\
**Last updated:** [April 18, 2019, 5:18am UTC](https://forum.fudiabetes.org/t/can-a-rotavirus-vaccine-prevent-type-1-diabetes-in-some-people/7255 "2019-04-18T05:18:50Z")

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I just wrote a new blog:

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## [New role model](https://forum.fudiabetes.org/t/new-role-model/7198)

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**Author:** [@savvv.05](https://forum.fudiabetes.org/u/savvv.05)\
**Replies:** 4\
**Last updated:** [April 12, 2019, 1:19pm UTC](https://forum.fudiabetes.org/t/new-role-model/7198 "2019-04-12T13:19:17Z")

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My college history professor is discussing WWII with us currently and we got on the topic of the Holocaust. She was talking about the struggles those at the concentration camps faced and it made me interested to know mor…

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